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Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-6415
Abstract: K-RAS mutation represents one of the most frequent genetic alterations in cancers. Monotherapy approaches targeting RAS downstream effectors such as MEK and ERK have had limited clinical success in patients with K-RAS-mutated cancers. The reduced…
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Keywords:
inhibitor;
mek inhibitor;
raf dimer;
dimer inhibitor ... See more keywords
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Published in 2021 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-rw2021-069
Abstract: Belvarafenib is active in BRAF- and NRAS-mutant tumors, but acquired ARAF mutations drive resistance.
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Keywords:
mutations limit;
limit response;
raf dimer;
araf mutations ... See more keywords