Ras-Mediated Activation of the Raf Family Kinases.
Sign Up to like & getrecommendations! Published in 2019 at "Cold Spring Harbor perspectives in medicine"
DOI: 10.1101/cshperspect.a033746
Abstract: The extracellular signal-regulated kinase (ERK) cascade comprised of the Raf, MEK, and ERK protein kinases constitutes a key effector cascade used by the Ras GTPases to relay signals regulating cell growth, survival, proliferation, and differentiation.… read more here.
Keywords: activation raf; ras mediated; raf activation; raf family ... See more keywords
Discovery of Raf Family Is a Milestone in Deciphering the Ras-Mediated Intracellular Signaling Pathway
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23095158
Abstract: The Ras-Raf-MEK-ERK signaling pathway, the first well-established MAPK pathway, plays essential roles in cell proliferation, survival, differentiation and development. It is activated in over 40% of human cancers owing to mutations of Ras, membrane receptor… read more here.
Keywords: raf family; discovery; raf; signaling pathway ... See more keywords