Pan-RAF inhibition induces apoptosis in acute myeloid leukemia cells and synergizes with BCL2 inhibition
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DOI: 10.1038/s41375-020-0972-0
Abstract: Pan-RAF inhibitors have shown promise as antitumor agents in RAS and RAF mutated solid cancers. However, the efficacy of pan-RAF inhibitors in acute myeloid leukemia (AML) has not previously been explored. In AML, the RAS–RAF–MEK–ERK… read more here.
Keywords: myeloid leukemia; inhibition; acute myeloid; raf inhibition ... See more keywords
Pan-RAF Inhibition Shows Anti-Leukemic Activity in RAS-Mutant Acute Myeloid Leukemia Cells and Potentiates the Effect of Sorafenib in Cells with FLT3 Mutation
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DOI: 10.3390/cancers12123511
Abstract: Simple Summary We demonstrate that the pan-RAF inhibitor LY3009120 induces apoptosis and inhibits proliferation in AML cells harboring RAS or FLT3 mutations through action on the RAS/RAF/MEK/ERK and the AKT/mTOR pathways. Notably, pan-RAF inhibition combined… read more here.
Keywords: inhibition; sorafenib; aml cells; raf inhibition ... See more keywords