Inhibition of mutant RAS-RAF interaction by mimicking structural and dynamic properties of phosphorylated RAS
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DOI: 10.1101/2022.04.24.489309
Abstract: Undruggability of RAS proteins has necessitated alternative strategies for the development of effective inhibitors. In this respect, phosphorylation has recently come into prominence as this reversible post-translational modification attenuates sensitivity of RAS towards RAF. As… read more here.
Keywords: inhibition mutant; ras raf; mutant; mutant ras ... See more keywords