Design, synthesis, and anticancer activity of imidazo[2,1-b]oxazole-based RAF kinase inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.103349
Abstract: In the present work, a novel series of B-RAF kinase inhibitors having imidazo[2,1-b]oxazole scaffold was designed and synthesized based on the structures of the well-known B-RAF inhibitors. The twenty two final compounds were tested over… read more here.
Keywords: kinase inhibitors; imidazo oxazole; raf; raf kinase ... See more keywords
A new regulatory mechanism for Raf kinase activation, retinoic acid-bound Crabp1
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-47354-7
Abstract: The rapidly accelerated fibrosarcoma (Raf) kinase is canonically activated by growth factors that regulate multiple cellular processes. In this kinase cascade Raf activation ultimately results in extracellular regulated kinase 1/2 (Erk1/2) activation, which requires Ras… read more here.
Keywords: raf; raf kinase; activation; retinoic acid ... See more keywords
Raf Kinase Inhibitory Protein regulates the cAMP-dependent protein kinase signaling pathway through a positive feedback loop
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2121867119
Abstract: Significance Cancer and heart disease are among the most progressive causes of mortality today. Two major regulators of these disease states are the MAP kinase and PKA signaling pathways. Ensuring proper signaling of these pathways… read more here.
Keywords: raf kinase; kinase inhibitory; kinase; positive feedback ... See more keywords
A patent review of RAF kinase inhibitors (2010–2018)
Sign Up to like & getrecommendations! Published in 2019 at "Expert Opinion on Therapeutic Patents"
DOI: 10.1080/13543776.2019.1651842
Abstract: ABSTRACT Introduction: RAF kinase inhibitors block and regulate RAS/RAF/MEK/ERK signaling, which is a key to tumor treatment. At present, although RAF kinase inhibitors have good efficacy, there are few such drugs with low toxicity, and… read more here.
Keywords: kinase inhibitors; 2010 2018; kinase; raf kinase ... See more keywords
Study of fatty acid profiles in fish wastes and in silico evaluation of unsaturated fatty acids for mutant B‐Raf kinase inhibition
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Food Process Engineering"
DOI: 10.1111/jfpe.13272
Abstract: Fish wastes include heads, intestines, fins, tails, and bones that are discarded in large quantity from fish processing industries. Substantial quantity of lipids and proteins can be extracted from these fish wastes to meet the… read more here.
Keywords: fatty acid; fatty acids; study; raf kinase ... See more keywords
Raf kinase inhibitory protein reduces bradykinin receptor desensitization
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.15614
Abstract: Inflammatory hyperalgesia represents a nociceptive phenotype that can become persistent in nature through dynamic protein modifications. However, a large gap in knowledge exists concerning how the integration of intracellular signaling molecules coordinates a persistent inflammatory… read more here.
Keywords: desensitization; bradykinin receptor; receptor desensitization; raf kinase ... See more keywords
Lensoside Aβ as an Adjuvant to the Anti-Glioma Potential of Sorafenib
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13112637
Abstract: Simple Summary Flavonoids are plant polyphenolic secondary metabolites, commonly consumed in the human diet. Lensoside Aβ is a quercetin glycoside isolated from the aerial parts of lentil (Lens culinaris) organs. The activity of this secondary… read more here.
Keywords: glioma; potential sorafenib; raf kinase; anti glioma ... See more keywords
Discovery of New Quinolone-Based Diarylamides as Potent B-RAFV600E/C-RAF Kinase Inhibitors Endowed with Promising In Vitro Anticancer Activity
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24043216
Abstract: The emergence of cancer resistance to targeted therapy represents a significant challenge in cancer treatment. Therefore, identifying new anticancer candidates, particularly those addressing oncogenic mutants, is an urgent medical demand. A campaign of structural modifications… read more here.
Keywords: raf; activity; rafv600e raf; cell lines ... See more keywords
A Comprehensive In Silico Exploration of Pharmacological Properties, Bioactivities, Molecular Docking, and Anticancer Potential of Vieloplain F from Xylopia vielana Targeting B-Raf Kinase
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DOI: 10.3390/molecules27030917
Abstract: Compounds derived from plants have several anticancer properties. In the current study, one guaiane-type sesquiterpene dimer, vieloplain F, isolated from Xylopia vielana species, was tested against B-Raf kinase protein (PDB: 3OG7), a potent target for… read more here.
Keywords: molecular docking; comprehensive silico; pharmacological properties; xylopia vielana ... See more keywords
Clinical and prognostic significance of Raf kinase inhibitory protein expression in gastrointestinal stromal tumors
Sign Up to like & getrecommendations! Published in 2018 at "World Journal of Gastroenterology"
DOI: 10.3748/wjg.v24.i23.2508
Abstract: AIM To detect the expression of Raf kinase inhibitory protein (RKIP) in gastrointestinal stromal tumors (GISTs) and to analyze its relationship with clinicopatholgical characteristics and prognosis of this disease. METHODS Sixty-three patients with pathologically diagnosed… read more here.
Keywords: prognosis; raf kinase; kinase inhibitory; expression ... See more keywords