Homogeneous Dual-Parametric-Coupled Assay for Simultaneous Nucleotide Exchange and KRAS/RAF-RBD Interaction Monitoring
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DOI: 10.1021/acs.analchem.9b05126
Abstract: We have developed a rapid and sensitive single-well dual-parametric method introduced in linked RAS nucleotide exchange and RAS/RAF-RBD interaction assays. RAS mutations are frequent drivers of multiple different human cancers, but the development of therapeutic… read more here.
Keywords: nucleotide exchange; exchange; interaction; dual parametric ... See more keywords