A B‐Raf V600E gene signature for melanoma predicts prognosis and reveals sensitivity to targeted therapies
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DOI: 10.1002/cam4.4491
Abstract: B‐Raf V600E mutations account for about half of all skin cutaneous melanoma cases, and patients with this mutation are sensitive to BRAF inhibitors. However, aberrations in other genes in the MAPK/ERK pathway may cascade a… read more here.
Keywords: prognosis; sensitivity; melanoma; signature ... See more keywords
A Look Inside of the Complex Pathogenesis of B-RAF(V600E)-Driven Cancer
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DOI: 10.7150/thno.20460
Abstract: Cancer is a very complex disease, where cell alterations (i.e. gene mutations, dysregulated signaling pathway(s) and epigenetic modifications) contribute to its development and progression. Elucidating the connections among these cell modifications is a critical challenge,… read more here.
Keywords: cancer; v600e driven; driven cancer; raf v600e ... See more keywords