Amyloid Beta Is Internalized via Macropinocytosis, an HSPG- and Lipid Raft-Dependent and Rac1-Mediated Process
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.804702
Abstract: Intracellular amyloid β peptide (Aβ) accumulation has drawn attention in relation to the pathophysiology of Alzheimer’s disease in addition to its extracellular deposition as senile plaque. Cellular uptake of extracellular Aβ is one of the… read more here.
Keywords: mediated process; lipid raft; amyloid; macropinocytosis ... See more keywords
Ubiquitin C-terminal Hydrolase L1 Regulates Lipid Raft-dependent Endocytosis
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Neurobiology"
DOI: 10.5607/en.2018.27.5.377
Abstract: Ubiquitin C-terminal hydrolase L1 (UCH-L1) is a deubiquitinating enzyme that is highly expressed in neurons, and gathering evidence indicates that UCH-L1 may play pathogenic roles in many neurodegenerative disorders such as Alzheimer's disease and Parkinson's… read more here.
Keywords: ubiquitin terminal; regulates lipid; raft dependent; dependent endocytosis ... See more keywords