Abrogation of B-RafV600E induced senescence by FoxM1 expression.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.06.144
Abstract: B-RafV600E oncogene mutation occurs in various cancers and is associated with tumor initiation. However, genetic modification of B-RafV600E in cells induces MAPK activation and results in oncogene-induced senescence. Overcoming the oncogene-induced senescence by B-RafV600E requires… read more here.
Keywords: foxm1 expression; rafv600e; induced senescence; senescence ... See more keywords
Critical role of miR-10b in B-RafV600E dependent anchorage independent growth and invasion of melanoma cells
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DOI: 10.1371/journal.pone.0204387
Abstract: Recent high-throughput-sequencing of cancer genomes has identified oncogenic mutations in the B-Raf genetic locus as one of the critical events in melanomagenesis. B-Raf encodes a serine/threonine kinase that regulates the MAPK/ERK kinase (MEK) and extracellular… read more here.
Keywords: melanoma; rafv600e; invasion; mir 10b ... See more keywords