Effect of Estriol, Chorionic Gonadotropin, and Oncostatin M on the Expression of Recombinase RAG-1 in Regulatory T Lymphocyte Subpopulations
Sign Up to like & getrecommendations! Published in 2019 at "Bulletin of Experimental Biology and Medicine"
DOI: 10.1007/s10517-019-04460-w
Abstract: We studied the effect of estriol, chorionic gonadotropin, oncostatin M, and hormone-cytokine combinations on the expression of recombinase RAG-1 in T-regulatory (Treg) and T helper 17 (Th17) lymphocytes. It was found that estriol in a… read more here.
Keywords: gonadotropin oncostatin; oncostatin; effect; chorionic gonadotropin ... See more keywords
Red American ginseng enhances the effect of fluorouracil on human colon cancer cells via both paraptosis and apoptosis pathways.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of applied biomedicine"
DOI: 10.1016/j.jab.2018.05.002
Abstract: Introduction As a commonly used chemotherapeutic agent, fluorouracil (5-FU) has serious dose-limiting side effects. In this study, we evaluated the synergy between red American ginseng (RAG) and 5-FU on human colorectal cancer cells, and explored… read more here.
Keywords: american ginseng; red american; cancer cells; cancer ... See more keywords
Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular cell"
DOI: 10.1016/j.molcel.2017.09.026
Abstract: mTOR complex I (mTORC1) is a central growth regulator that senses amino acids through a pathway that converges on the Rag GTPases, an obligate heterodimer of two related GTPases. Despite their central role in amino… read more here.
Keywords: amino acid; rapidly amino; respond rapidly; rag gtpases ... See more keywords
Regulation of mTORC1 by the Rag GTPases
Sign Up to like & getrecommendations! Published in 2023 at "Biochemical Society Transactions"
DOI: 10.1042/bst20210038
Abstract: The Rag GTPases are an evolutionarily conserved family that play a crucial role in amino acid sensing by the mammalian target of rapamycin complex 1 (mTORC1). mTORC1 is often referred to as the master regulator… read more here.
Keywords: regulation mtorc1; mtorc1 rag; amino acid; rag ... See more keywords
Sequence-dependent dynamics of synthetic and endogenous RSSs in V(D)J recombination
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa418
Abstract: Abstract Developing lymphocytes of jawed vertebrates cleave and combine distinct gene segments to assemble antigen–receptor genes. This process called V(D)J recombination that involves the RAG recombinase binding and cutting recombination signal sequences (RSSs) composed of… read more here.
Keywords: dependent dynamics; rag; synthetic endogenous; recombination ... See more keywords
The RAG-2 Inhibitory Domain Gates Accessibility of the V(D)J Recombinase to Chromatin
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and Cellular Biology"
DOI: 10.1128/mcb.00159-18
Abstract: Accessibility of antigen receptor loci to RAG is correlated with the presence of H3K4me3, which binds to a plant homeodomain (PHD) in the RAG-2 subunit and promotes V(D)J recombination. A point mutation in the PHD,… read more here.
Keywords: recombination; h3k4me3; inhibitory domain; rag ... See more keywords
Nonamer dependent RAG cleavage at CpGs can explain mechanism of chromosomal translocations associated to lymphoid cancers
Sign Up to like & getrecommendations! Published in 2022 at "PLOS Genetics"
DOI: 10.1371/journal.pgen.1010421
Abstract: Chromosomal translocations are considered as one of the major causes of lymphoid cancers. RAG complex, which is responsible for V(D)J recombination, can also cleave non-B DNA structures and cryptic RSSs in the genome leading to… read more here.
Keywords: lymphoid cancers; cleavage; chromosomal translocations; cpgs ... See more keywords
Measurement of resilience potential - development of a resilience assessment grid for emergency departments
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0239472
Abstract: Background Resilience engineering has been advocated as an alternative to the management of safety over the last decade in many domains. However, to facilitate metrics for measuring and helping analyze the resilience potential for emergency… read more here.
Keywords: resilience assessment; resilience potential; emergency departments; assessment grid ... See more keywords
The application of resilience assessment grid in healthcare: A scoping review
Sign Up to like & getrecommendations! Published in 2022 at "PLOS ONE"
DOI: 10.1371/journal.pone.0277289
Abstract: Background The Resilience Assessment Grid (RAG) has attracted increasing interest in recent healthcare discourse as an instrument to understand and measure the resilience performance of socio-technical systems. Despite its growing popularity in healthcare, its applicability… read more here.
Keywords: resilience; application; assessment grid; resilience assessment ... See more keywords
MiRAGDB: A Knowledgebase of RAG Regulators
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.863110
Abstract: RAG1 and RAG2 genes generate diversity in immunoglobulin and TCR genes by initiating the process of V-D-J recombination. RAGs recognize specific sequences (heptamer-nonamer) to generate a diversity of immunoglobulins. RAG expression is limited to early… read more here.
Keywords: miragdb knowledgebase; rag regulators; knowledgebase rag; expression ... See more keywords