Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular cell"
DOI: 10.1016/j.molcel.2017.09.026
Abstract: mTOR complex I (mTORC1) is a central growth regulator that senses amino acids through a pathway that converges on the Rag GTPases, an obligate heterodimer of two related GTPases. Despite their central role in amino… read more here.
Keywords: amino acid; rapidly amino; respond rapidly; rag gtpases ... See more keywords
KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1
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DOI: 10.1038/nature21423
Abstract: The mechanistic target of rapamycin complex 1 (mTORC1) is a central regulator of cell growth that responds to diverse environmental signals and is deregulated in many human diseases, including cancer and epilepsy. Amino acids are… read more here.
Keywords: kicstor; kicstor recruits; mtorc1 signalling; rag gtpases ... See more keywords
Regulation of mTORC1 by the Rag GTPases
Sign Up to like & getrecommendations! Published in 2023 at "Biochemical Society Transactions"
DOI: 10.1042/bst20210038
Abstract: The Rag GTPases are an evolutionarily conserved family that play a crucial role in amino acid sensing by the mammalian target of rapamycin complex 1 (mTORC1). mTORC1 is often referred to as the master regulator… read more here.
Keywords: regulation mtorc1; mtorc1 rag; amino acid; rag ... See more keywords