Multipotent RAG1+ progenitors emerge directly from haemogenic endothelium in human pluripotent stem cell-derived haematopoietic organoids
Sign Up to like & getrecommendations! Published in 2020 at "Nature Cell Biology"
DOI: 10.1038/s41556-019-0445-8
Abstract: Defining the ontogeny of the human adaptive immune system during embryogenesis has implications for understanding childhood diseases including leukaemias and autoimmune conditions. Using RAG1:GFP human pluripotent stem cell reporter lines, we examined human T-cell genesis… read more here.
Keywords: rag1; directly haemogenic; stem cell; pluripotent stem ... See more keywords
Expression and clinical significance of RAG1 in myelodysplastic syndromes
Sign Up to like & getrecommendations! Published in 2022 at "Hematology"
DOI: 10.1080/16078454.2022.2127462
Abstract: Objective To determine the expression level of RAG1 and its clinical significance in myelodysplastic syndromes (MDS). Methods To explore the candidate genes, the microarray datasets GSE19429, GSE58831, and GSE2779 were downloaded from the Gene Expression… read more here.
Keywords: clinical significance; myelodysplastic syndromes; expression; rag1 ... See more keywords
Abstract 610: Modeling tumor immunoediting coupled with T-cell repertoire dynamic
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-610
Abstract: As tumors evolve, cancer cells acquire somatic mutations and these mutations generate tumor specific neoantigens that are different from self and can be recognized by T-cells, inducing anti-tumor immune responses. Such immunogenic antigens can be… read more here.
Keywords: cell; immune competent; rag1; mice ... See more keywords
Interaction between Rag genes results in a unique synergistic transcriptional response that enhances soybean resistance to soybean aphids
Sign Up to like & getrecommendations! Published in 2021 at "BMC Genomics"
DOI: 10.1186/s12864-021-08147-3
Abstract: Background Pyramiding different resistance genes into one plant genotype confers enhanced resistance at the phenotypic level, but the molecular mechanisms underlying this effect are not well-understood. In soybean, aphid resistance is conferred by Rag genes.… read more here.
Keywords: response; rag1; soybean; rag genes ... See more keywords
Whole-exome sequencing identified a homozygous novel RAG1 mutation in a child with omenn syndrome.
Sign Up to like & getrecommendations! Published in 2022 at "Allergologia et immunopathologia"
DOI: 10.15586/aei.v50i6.529
Abstract: INTRODUCTION AND OBJECTIVES Omenn syndrome (OS) is a very rare type of severe combined immunodeficiencies manifested with erythroderma, eosinophilia, hepatosplenomegaly, lymph-adenopathy, and elevated level of serum IgE. OS is inherited with an autosomal recessive mode… read more here.
Keywords: omenn syndrome; whole exome; rag1; sequencing identified ... See more keywords
MiRAGDB: A Knowledgebase of RAG Regulators
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.863110
Abstract: RAG1 and RAG2 genes generate diversity in immunoglobulin and TCR genes by initiating the process of V-D-J recombination. RAGs recognize specific sequences (heptamer-nonamer) to generate a diversity of immunoglobulins. RAG expression is limited to early… read more here.
Keywords: miragdb knowledgebase; rag regulators; knowledgebase rag; expression ... See more keywords
Development and characterization of a CRISPR/Cas9-mediated RAG1 knockout chicken model lacking mature B and T cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.892476
Abstract: Although birds have been used historically as a model animal for immunological research, resulting in remarkable achievements, immune cell development in birds themselves has yet to be fully elucidated. In this study, we firstly generated… read more here.
Keywords: development; rag1; cell; chicken model ... See more keywords
Spi-C and PU.1 Counterregulate Rag1 and Igκ Transcription to Effect Vκ-Jκ Recombination in Small Pre-B Cells.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of immunology"
DOI: 10.4049/jimmunol.2300122
Abstract: B cell development requires the ordered rearrangement of Ig genes encoding H and L chain proteins that assemble into BCRs or Abs capable of recognizing specific Ags. Igκ rearrangement is promoted by chromatin accessibility and… read more here.
Keywords: small pre; transcription; pre cells; rag1 ... See more keywords