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   Articles with "rag1" as a keyword



RAG1/2 induces double‐stranded DNA breaks at non‐Ig loci in the proximity of single sequence repeats in developing B cells

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recommendations! Published in 2024 at "European Journal of Immunology"

DOI: 10.1002/eji.202350958

Abstract: In developing B cells, V(D)J gene recombination is initiated by the RAG1/2 endonuclease complex, introducing double‐stranded DNA breaks (DSBs) in V, D, and J genes and resulting in the formation of the hypervariable parts of… read more here.

Keywords: stranded dna; double stranded; developing cells; rag1 ... See more keywords

Evolutionary preservation of CpG dinucleotides in RAG1 may elucidate the relatively high rate of methylation-mediated mutagenesis of RAG1 transposase

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recommendations! Published in 2024 at "Immunologic Research"

DOI: 10.1007/s12026-023-09451-8

Abstract: Recombination-activating gene 1 (RAG1) is a vital player in V(D)J recombination, a fundamental process in primary B cell and T cell receptor diversification of the adaptive immune system. Current vertebrate RAG evolved from RAG transposon;… read more here.

Keywords: mutagenesis; cpg dinucleotides; cpg; rag1 ... See more keywords

Multipotent RAG1+ progenitors emerge directly from haemogenic endothelium in human pluripotent stem cell-derived haematopoietic organoids

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recommendations! Published in 2020 at "Nature Cell Biology"

DOI: 10.1038/s41556-019-0445-8

Abstract: Defining the ontogeny of the human adaptive immune system during embryogenesis has implications for understanding childhood diseases including leukaemias and autoimmune conditions. Using RAG1:GFP human pluripotent stem cell reporter lines, we examined human T-cell genesis… read more here.

Keywords: rag1; directly haemogenic; stem cell; pluripotent stem ... See more keywords

Expression and clinical significance of RAG1 in myelodysplastic syndromes

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recommendations! Published in 2022 at "Hematology"

DOI: 10.1080/16078454.2022.2127462

Abstract: Objective To determine the expression level of RAG1 and its clinical significance in myelodysplastic syndromes (MDS). Methods To explore the candidate genes, the microarray datasets GSE19429, GSE58831, and GSE2779 were downloaded from the Gene Expression… read more here.

Keywords: clinical significance; myelodysplastic syndromes; expression; rag1 ... See more keywords

Abstract 610: Modeling tumor immunoediting coupled with T-cell repertoire dynamic

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recommendations! Published in 2023 at "Cancer Research"

DOI: 10.1158/1538-7445.am2023-610

Abstract: As tumors evolve, cancer cells acquire somatic mutations and these mutations generate tumor specific neoantigens that are different from self and can be recognized by T-cells, inducing anti-tumor immune responses. Such immunogenic antigens can be… read more here.

Keywords: cell; immune competent; rag1; mice ... See more keywords

Whole-Genome Sequencing of 95 Japanese Patients with Pediatric Acute Myeloid Leukemia

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recommendations! Published in 2024 at "Blood"

DOI: 10.1182/blood-2024-200476

Abstract: Background Pediatric acute myeloid leukemia (pAML) is one of the main causes of death in pediatric oncology. Most previous studies on the genetics of pAML are limited to exome or targeted sequencing, and the genome-wide… read more here.

Keywords: pediatric acute; acute myeloid; whole genome; genome ... See more keywords

The Hypomethylating Agent 5-Aza-4‘-Thio-2‘-Deoxycytidine Targets Early B Progenitor Cells and Leads to B Cell Precursor Acute Lymphoblastic Leukemia in Rag1 Knockout Mice

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recommendations! Published in 2024 at "Blood"

DOI: 10.1182/blood-2024-208171

Abstract: 5-Aza-4'-thio-2'-deoxycytidine (Aza TdCyd or ATC) is a cytidine analog used as a promising DNA methyl transferase inhibitor (DNMTi) in preclinical studies against solid tumors. Previously, we demonstrated that ATC functions as a potent mutagen capable… read more here.

Keywords: mice; treatment; rag1; cell ... See more keywords

Interaction between Rag genes results in a unique synergistic transcriptional response that enhances soybean resistance to soybean aphids

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recommendations! Published in 2021 at "BMC Genomics"

DOI: 10.1186/s12864-021-08147-3

Abstract: Background Pyramiding different resistance genes into one plant genotype confers enhanced resistance at the phenotypic level, but the molecular mechanisms underlying this effect are not well-understood. In soybean, aphid resistance is conferred by Rag genes.… read more here.

Keywords: response; rag1; soybean; rag genes ... See more keywords

Whole-exome sequencing identified a homozygous novel RAG1 mutation in a child with omenn syndrome.

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recommendations! Published in 2022 at "Allergologia et immunopathologia"

DOI: 10.15586/aei.v50i6.529

Abstract: INTRODUCTION AND OBJECTIVES Omenn syndrome (OS) is a very rare type of severe combined immunodeficiencies manifested with erythroderma, eosinophilia, hepatosplenomegaly, lymph-adenopathy, and elevated level of serum IgE. OS is inherited with an autosomal recessive mode… read more here.

Keywords: omenn syndrome; whole exome; rag1; sequencing identified ... See more keywords

MiRAGDB: A Knowledgebase of RAG Regulators

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recommendations! Published in 2022 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2022.863110

Abstract: RAG1 and RAG2 genes generate diversity in immunoglobulin and TCR genes by initiating the process of V-D-J recombination. RAGs recognize specific sequences (heptamer-nonamer) to generate a diversity of immunoglobulins. RAG expression is limited to early… read more here.

Keywords: miragdb knowledgebase; rag regulators; knowledgebase rag; expression ... See more keywords

Development and characterization of a CRISPR/Cas9-mediated RAG1 knockout chicken model lacking mature B and T cells

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recommendations! Published in 2022 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2022.892476

Abstract: Although birds have been used historically as a model animal for immunological research, resulting in remarkable achievements, immune cell development in birds themselves has yet to be fully elucidated. In this study, we firstly generated… read more here.

Keywords: development; rag1; cell; chicken model ... See more keywords