Clinical value of RAG1 expression and IKZF1 deletions in Philadelphia negative pediatric B cell precursor acute lymphoblastic leukemia
Sign Up to like & getrecommendations! Published in 2020 at "Pediatric Hematology and Oncology"
DOI: 10.1080/08880018.2020.1767739
Abstract: Abstract This study aimed to address the clinical impact of recombination-activating gene (RAG1) expression and tumor suppressor IKZF1 gene deletions in Philadelphia negative B-cell precursor acute lymphoblastic leukemia (B-ALL) patients. Fifty newly diagnosed pediatric Philadelphia… read more here.
Keywords: cell; philadelphia negative; rag1 expression; expression ... See more keywords
Abstract 5507:RAG1high expression associated withIKZF1dysfunction in adult B-cell acute lymphoblastic leukemia
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-5507
Abstract: The recombination activating gene (RAG)-mediated recombination is the dominant mutational process and the predominant driver of oncogenic genomic rearrangement in acute lymphoblastic leukemia (ALL). This then leads to further leukemic clonal evolution. IKZF1 encodes a… read more here.
Keywords: adult; lymphoblastic leukemia; rag1 expression; expression ... See more keywords