The R229Q mutation of Rag2 does not characterize severe immunodeficiency in mice
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-39496-5
Abstract: RAG1 or RAG2 mutations are associated with defects in V(D)J recombination activity, causing severe immunodeficiency with a wide spectrum of clinical phenotypes. A R229Q mutation of RAG2 was identified in patients with severe combined immunodeficiency… read more here.
Keywords: severe immunodeficiency; rag2; r229q mutation; mutation ... See more keywords
Increased Polymerase Activity of Zoonotic H7N9 Allows Partial Escape from MxA
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14112331
Abstract: The interferon-induced myxovirus resistance protein A (MxA) is a potent restriction factor that prevents zoonotic infection from influenza A virus (IAV) subtype H7N9. Individuals expressing antivirally inactive MxA variants are highly susceptible to these infections.… read more here.
Keywords: mxa escape; rag2; h7n9; escape mxa ... See more keywords