Abstract LB-023: CYP monooxygenases regulate nuclear localization of ERá and mTORC1 component RagC in ER+HER2- breast cancer cells
Sign Up to like & getrecommendations! Published in 2019 at "Endocrinology"
DOI: 10.1158/1538-7445.am2019-lb-023
Abstract: Introduction: Cancer cell-intrinsic CYP monooxygenases promote tumor progression. In ER+ breast cancer cells, CYP3A4 is required for tumor growth and localizes to mitochondria where it promotes electron transport chain and respiration, while suppressing autophagy, in… read more here.
Keywords: her2 breast; cancer cells; cancer; breast cancer ... See more keywords
Folliculin promotes substrate-selective mTORC1 activity by activating RagC to recruit TFE3.
Sign Up to like & getrecommendations! Published in 2022 at "PLoS biology"
DOI: 10.1371/journal.pbio.3001594
Abstract: Mechanistic target of rapamycin complex I (mTORC1) is central to cellular metabolic regulation. mTORC1 phosphorylates a myriad of substrates, but how different substrate specificity is conferred on mTORC1 by different conditions remains poorly defined. Here,… read more here.
Keywords: folliculin; tfe3; mtorc1; recruit tfe3 ... See more keywords