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   Articles with "rage" as a keyword



Glycated ECM Derived Carbon Dots Inhibit Tumor Vasculogenic Mimicry by Disrupting RAGE Nuclear Translocation and Its Interaction With HMGB1

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recommendations! Published in 2025 at "Advanced Materials"

DOI: 10.1002/adma.202419540

Abstract: This study investigates the role of advanced glycation end‐products (AGEs) in tumor vasculogenic mimicry (VM). Using high‐sugar diet animal models and glycated extracellular matrix (ECM) ex vivo models, AGEs derived is demonstrated from glycated ECM… read more here.

Keywords: glycated ecm; carbon dots; tumor; rage ... See more keywords

A Novel RAGE Modulator Induces Soluble RAGE to Reduce BACE1 Expression in Alzheimer's Disease (Adv. Sci. 8/2025)

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recommendations! Published in 2025 at "Advanced Science"

DOI: 10.1002/advs.202570050

Abstract: Repurposing an Old Drug for Alzheimer's Disease In article number 2407812, Dong‐Gyu Jo and co‐workers propose a novel strategy for Alzheimer's disease (AD) treatment, demonstrating that the anticancer agent 6‐thioguanosine (6‐TG) interacts with the receptor… read more here.

Keywords: rage; soluble rage; alzheimer disease; bace1 expression ... See more keywords

Oxymatrine attenuates sepsis‐induced inflammation and organ injury via inhibition of HMGB1/RAGE/NF‐κB signaling pathway

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recommendations! Published in 2024 at "Drug Development Research"

DOI: 10.1002/ddr.22219

Abstract: Sepsis is a life‐threatening organ dysfunction that endangers patient lives and is caused by an imbalance in the host defense against infection. Sepsis continues to be a significant cause of morbidity and mortality in critically… read more here.

Keywords: rage signaling; hmgb1 rage; rage; sepsis ... See more keywords

Differential gene expression analysis of RAGE‐S100A6 complex for target selection and the design of novel inhibitors for anticancer drug discovery

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recommendations! Published in 2022 at "Journal of Cellular Biochemistry"

DOI: 10.1002/jcb.30356

Abstract: Receptor for advanced glycation end products (RAGE), a member of the immunoglobulin family, interactions with its ligands trigger downstream signaling and induce an inflammatory response linked to diabetes, inflammation, carcinogenesis, cardiovascular disease, and a variety… read more here.

Keywords: rage; rage s100a6; s100a6 complex; differential gene ... See more keywords

RAGE is a potential biomarker implicated in immune infiltrates and cellular senescence in lung adenocarcinoma

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recommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"

DOI: 10.1002/jcla.24382

Abstract: Receptor for Advanced Glycation End‐products (RAGE) is an oncogene abnormally expressed in various cancers. However, the clinical value of RAGE and the biological role of RAGE in lung cancer have not been fully investigated. read more here.

Keywords: implicated immune; potential biomarker; rage; lung ... See more keywords
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Effects of nebulized N­‐acetylcystein on the expression of HMGB1 and RAGE in rats with hyperoxia‐­induced lung injury

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recommendations! Published in 2019 at "Journal of Cellular Physiology"

DOI: 10.1002/jcp.27724

Abstract: To investigate the role of high mobility group box 1 (HMGB1) and receptor for advanced glycation end product (RAGE) in the lungs of hyperoxia‐induced rats and the effect of N‐acetlycystein (NAC). read more here.

Keywords: hmgb1; hyperoxia induced; effects nebulized; rage ... See more keywords
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Activation of RAGE leads to the release of glutamate from astrocytes and stimulates calcium signal in neurons

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recommendations! Published in 2021 at "Journal of Cellular Physiology"

DOI: 10.1002/jcp.30324

Abstract: The receptor for advanced glycation end products (RAGE) is a signal receptor first shown to be activated by advanced glycation end products, but also by a variety of signal molecules, including pathological advanced oxidation protein… read more here.

Keywords: activation rage; glutamate astrocytes; physiology; rage ... See more keywords

Targeting RAGE prevents muscle wasting and prolongs survival in cancer cachexia

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recommendations! Published in 2020 at "Journal of Cachexia, Sarcopenia and Muscle"

DOI: 10.1002/jcsm.12561

Abstract: Abstract Background Cachexia, a multifactorial syndrome affecting more than 50% of patients with advanced cancer and responsible for ~20% of cancer‐associated deaths, is still a poorly understood process without a standard cure available. Skeletal muscle… read more here.

Keywords: muscle; muscle wasting; rage; cancer cachexia ... See more keywords

HMGB1‐RAGE signaling facilitates Ras‐dependent Yap1 expression to drive colorectal cancer stemness and development

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recommendations! Published in 2019 at "Molecular Carcinogenesis"

DOI: 10.1002/mc.22944

Abstract: HMGB1‐RAGE signaling plays an integral role in inflammation‐driven carcinogenesis. In the present study, we showed that RAGE has direct association with K‐Ras following HMGB1 exposure in colorectal cancer (CRC) cells. Immunofluorescence analysis revealed a significant… read more here.

Keywords: hmgb1 rage; ras dependent; expression; rage ... See more keywords

Lucidone inhibits autophagy and MDR1 via HMGB1/RAGE/PI3K/Akt signaling pathway in pancreatic cancer cells

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recommendations! Published in 2022 at "Phytotherapy Research"

DOI: 10.1002/ptr.7385

Abstract: Gemcitabine (GEM) drug resistance remains a difficult challenge in pancreatic ductal adenocarcinoma (PDAC) treatment. Therefore, identifying a safe and effective treatment strategy for PDAC is urgent. Lucidone is a natural compound extracted from the fruits… read more here.

Keywords: pi3k akt; rage pi3k; rage; hmgb1 rage ... See more keywords

Plantamajoside attenuates cardiac fibrosis via inhibiting AGEs activated‐RAGE/autophagy/EndMT pathway

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recommendations! Published in 2022 at "Phytotherapy Research"

DOI: 10.1002/ptr.7663

Abstract: Advanced glycation end products (AGEs) have been identified to transduce fibrogenic signals via inducing the activation of their receptor (RAGE)‐mediated pathway. Recently, disrupting AGE‐RAGE interaction has become a promising therapeutic strategy for chronic heart failure… read more here.

Keywords: cardiac fibrosis; rage autophagy; rage; fibrosis ... See more keywords