Differential gene expression analysis of RAGE‐S100A6 complex for target selection and the design of novel inhibitors for anticancer drug discovery
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30356
Abstract: Receptor for advanced glycation end products (RAGE), a member of the immunoglobulin family, interactions with its ligands trigger downstream signaling and induce an inflammatory response linked to diabetes, inflammation, carcinogenesis, cardiovascular disease, and a variety… read more here.
Keywords: rage; rage s100a6; s100a6 complex; differential gene ... See more keywords
RAGE is a potential biomarker implicated in immune infiltrates and cellular senescence in lung adenocarcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24382
Abstract: Receptor for Advanced Glycation End‐products (RAGE) is an oncogene abnormally expressed in various cancers. However, the clinical value of RAGE and the biological role of RAGE in lung cancer have not been fully investigated. read more here.
Keywords: implicated immune; potential biomarker; rage; lung ... See more keywords
Effects of nebulized N‐acetylcystein on the expression of HMGB1 and RAGE in rats with hyperoxia‐induced lung injury
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27724
Abstract: To investigate the role of high mobility group box 1 (HMGB1) and receptor for advanced glycation end product (RAGE) in the lungs of hyperoxia‐induced rats and the effect of N‐acetlycystein (NAC). read more here.
Keywords: hmgb1; hyperoxia induced; effects nebulized; rage ... See more keywords
Activation of RAGE leads to the release of glutamate from astrocytes and stimulates calcium signal in neurons
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30324
Abstract: The receptor for advanced glycation end products (RAGE) is a signal receptor first shown to be activated by advanced glycation end products, but also by a variety of signal molecules, including pathological advanced oxidation protein… read more here.
Keywords: activation rage; glutamate astrocytes; physiology; rage ... See more keywords
Targeting RAGE prevents muscle wasting and prolongs survival in cancer cachexia
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.12561
Abstract: Abstract Background Cachexia, a multifactorial syndrome affecting more than 50% of patients with advanced cancer and responsible for ~20% of cancer‐associated deaths, is still a poorly understood process without a standard cure available. Skeletal muscle… read more here.
Keywords: muscle; muscle wasting; rage; cancer cachexia ... See more keywords
HMGB1‐RAGE signaling facilitates Ras‐dependent Yap1 expression to drive colorectal cancer stemness and development
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.22944
Abstract: HMGB1‐RAGE signaling plays an integral role in inflammation‐driven carcinogenesis. In the present study, we showed that RAGE has direct association with K‐Ras following HMGB1 exposure in colorectal cancer (CRC) cells. Immunofluorescence analysis revealed a significant… read more here.
Keywords: hmgb1 rage; ras dependent; expression; rage ... See more keywords
Lucidone inhibits autophagy and MDR1 via HMGB1/RAGE/PI3K/Akt signaling pathway in pancreatic cancer cells
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7385
Abstract: Gemcitabine (GEM) drug resistance remains a difficult challenge in pancreatic ductal adenocarcinoma (PDAC) treatment. Therefore, identifying a safe and effective treatment strategy for PDAC is urgent. Lucidone is a natural compound extracted from the fruits… read more here.
Keywords: pi3k akt; rage pi3k; rage; hmgb1 rage ... See more keywords
Plantamajoside attenuates cardiac fibrosis via inhibiting AGEs activated‐RAGE/autophagy/EndMT pathway
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DOI: 10.1002/ptr.7663
Abstract: Advanced glycation end products (AGEs) have been identified to transduce fibrogenic signals via inducing the activation of their receptor (RAGE)‐mediated pathway. Recently, disrupting AGE‐RAGE interaction has become a promising therapeutic strategy for chronic heart failure… read more here.
Keywords: cardiac fibrosis; rage autophagy; rage; fibrosis ... See more keywords
Relationship between RAGE gene polymorphisms and cardiovascular disease prognosis in the Chinese Han population
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Genetics and Genomics"
DOI: 10.1007/s00438-017-1341-1
Abstract: Abstract Cardiovascular disease (CVD) is the leading cause of death in China. This study aimed to investigate whether RAGE gene polymorphisms are associated with the prognosis of various cardiovascular diseases in the Chinese Han population.… read more here.
Keywords: chinese han; prognosis; han population; rage ... See more keywords
RAGE-TLR Crosstalk Sustains Chronic Inflammation in Neurodegeneration
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DOI: 10.1007/s12035-017-0419-4
Abstract: Chronic inflammatory reactions are consistenly present in neurodegeneration of Alzheimer type and are considered important factors that accelerate progression of the disease. Receptors of innate immunity participate in triggering and driving inflammatory reactions. For example,… read more here.
Keywords: tlr crosstalk; inflammation; chronic inflammation; rage tlr ... See more keywords
RAGE-NF-κB-PPARγ Signaling is Involved in AGEs-Induced Upregulation of Amyloid-β Influx Transport in an In Vitro BBB Model
Sign Up to like & getrecommendations! Published in 2017 at "Neurotoxicity Research"
DOI: 10.1007/s12640-017-9784-z
Abstract: The receptor for advanced glycation end products (RAGE) at the blood-brain barrier (BBB) is critical for regulation of amyloid-β (Aβ) homeostasis in the diabetic brain. In this study, we used an in vitro BBB model… read more here.
Keywords: ppar; ages induced; bbb; transport ... See more keywords