HMGB1‐RAGE signaling facilitates Ras‐dependent Yap1 expression to drive colorectal cancer stemness and development
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.22944
Abstract: HMGB1‐RAGE signaling plays an integral role in inflammation‐driven carcinogenesis. In the present study, we showed that RAGE has direct association with K‐Ras following HMGB1 exposure in colorectal cancer (CRC) cells. Immunofluorescence analysis revealed a significant… read more here.
Keywords: hmgb1 rage; ras dependent; expression; rage ... See more keywords
HMGB1 Mediates Paraquat-Induced Neuroinflammatory Responses via Activating RAGE Signaling Pathway
Sign Up to like & getrecommendations! Published in 2019 at "Neurotoxicity Research"
DOI: 10.1007/s12640-019-00148-1
Abstract: Paraquat (PQ), a widely characterized neurotoxicant, has been generally accepted as one of the environmental factors in the etiology of Parkinson’s disease (PD). Despite the direct evidence that PQ could induce inflammatory responses in central… read more here.
Keywords: neuroinflammatory responses; activating rage; via activating; signaling pathway ... See more keywords
Inhibition of phosphodiesterase-4 suppresses HMGB1/RAGE signaling pathway and NLRP3 inflammasome activation in mice exposed to chronic unpredictable mild stress
Sign Up to like & getrecommendations! Published in 2021 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2020.11.029
Abstract: Inhibition of phosphodiesterase-4 (PDE4) produces robust anti-inflammatory and antidepressant-like effects in multiple animal models. However, the detailed mechanisms have not been well studied. Receptor for advanced glycation endproducts (RAGE) and inflammasome activation are implicated in… read more here.
Keywords: hmgb1 rage; inhibition; signaling pathway; rage ... See more keywords
Inflammatory cytokine elaboration following secondhand smoke exposure is mediated in part by RAGE signaling
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5733440
Abstract: The receptor for advanced glycation end products (RAGE) is a key contributor to the immune and inflammatory response in a myriad of diseases. RAGE is a transmembrane pattern recognition receptor with special interest in pulmonary… read more here.
Keywords: secondhand smoke; rage; physiology; rage signaling ... See more keywords
Blocking AGE-RAGE Signaling Improved Functional Disorders of Macrophages in Diabetic Wound
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Diabetes Research"
DOI: 10.1155/2017/1428537
Abstract: Advanced glycosylation end products (AGEs) accumulate in diabetic wounds. Interactions between AGEs and their receptor (RAGE) leads to dermatologic problems in diabetes. Macrophage, which plays important roles in wound healing, highly expresses RAGE. Therefore, we… read more here.
Keywords: blocking age; rage; signaling improved; age rage ... See more keywords
Lycopene Improves Bone Quality and Regulates AGE/RAGE/NF-кB Signaling Pathway in High-Fat Diet-Induced Obese Mice
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/3697067
Abstract: Objective This study was aimed at examining the effects of lycopene on bone metabolism in high-fat diet (HFD)- induced obese mice and to identify the potential underlying mechanisms. Methods Mice were fed a HFD for… read more here.
Keywords: signaling pathway; age rage; obese mice; induced obese ... See more keywords
Mechanistic Study of Schisandra chinensis Fruit Mixture Based on Network Pharmacology, Molecular Docking and Experimental Validation to Improve the Inflammatory Response of DKD Through AGEs/RAGE Signaling Pathway
Sign Up to like & getrecommendations! Published in 2023 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s395512
Abstract: Background Diabetic kidney disease (DKD) is a major cause of end-stage renal disease (ESRD), and inflammation is the main causative mechanism. Schisandra chinensis fruit Mixture (SM) is an herbal formulation that has been used for… read more here.
Keywords: molecular docking; dkd; signaling pathway; pharmacology ... See more keywords
Role and therapeutic potential of RAGE signaling in neurodegeneration.
Sign Up to like & getrecommendations! Published in 2022 at "Current drug targets"
DOI: 10.2174/1389450123666220610171005
Abstract: Activation of the receptor for advanced glycation end products (RAGE) has been shown to play an active role in the development of multiple neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Amyotrophic Lateral Sclerosis. Although… read more here.
Keywords: therapeutic potential; rage; role therapeutic; rage signaling ... See more keywords
RAGE signaling regulates the progression of diabetic complications
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1128872
Abstract: Diabetes, the ninth leading cause of death globally, is expected to affect 642 million people by 2040. With the advancement of an aging society, the number of patients with diabetes having multiple underlying diseases, such… read more here.
Keywords: signaling regulates; diabetic complications; progression; rage ... See more keywords
Xanthohumol alleviated T2DM-induced liver steatosis and fibrosis by mediating the NRF2/RAGE/NF-κB signaling pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Future medicinal chemistry"
DOI: 10.4155/fmc-2021-0241
Abstract: Hyperglycemia-associated advanced glycation end products (AGEs) and the receptor for AGE (RAGE) contribute to nonalcoholic fatty liver disease (NAFLD). Xanthohumol (XH) exhibits protective activities against liver diseases. Aim: To investigate the effects of XH on Type II diabetes mellitus (T2DM)-induced… read more here.
Keywords: liver steatosis; steatosis fibrosis; t2dm induced; induced liver ... See more keywords