Membrane extraction by calmodulin underpins the disparate signalling of RalA and RalB
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DOI: 10.1002/bies.202200011
Abstract: Both RalA and RalB interact with the ubiquitous calcium sensor, calmodulin (CaM). New structural and biophysical characterisation of these interactions strongly suggests that, in the native membrane‐associated state, only RalA can be extracted from the… read more here.
Keywords: rala ralb; rala; membrane; disparate signalling ... See more keywords
Identification of RALA as a Therapeutic Target and Prognostic Predictor of Osteosarcoma
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DOI: 10.1155/2023/1150768
Abstract: Background Osteosarcoma (OS) is the most common primary aggressive sarcoma of bone, with massive aberrant expression of oncogenes related to the development of OS. RALA, a kind of small Ras-like guanosine triphosphatases, has been identified… read more here.
Keywords: therapeutic target; osteosarcoma; expression; rala ... See more keywords
Single-cell resolution reveals RalA GTPase expanding hematopoietic stem cells and facilitating of BCR-ABL1-driven leukemogenesis in a CRISPR/Cas9 gene editing mouse model
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Biological Sciences"
DOI: 10.2139/ssrn.4159580
Abstract: BCR-ABL oncogene-mediated Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) is suggested to originate from leukemic stem cells (LSCs); however, factors regulating self-renewal of LSC and normal hematopoietic stem cells (HSCs) are largely unclear. Here, we… read more here.
Keywords: cell; rala; single cell; stem cells ... See more keywords
RCC2 Interacts with Small GTPase RalA and Regulates Cell Proliferation and Motility in Gastric Cancer
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DOI: 10.2147/ott.s228914
Abstract: Background Regulator of chromosome condensation 2 (RCC2), also known as TD-60, is associated with various human malignant cancers. RCC2 has been shown to exhibit guanine exchange factor (GEF) activity and contribute to early mitosis. However,… read more here.
Keywords: rcc2; cell proliferation; cancer; gastric cancer ... See more keywords
Non-viral gene delivery utilizing RALA modulates sFlt-1 secretion, important for preeclampsia.
Sign Up to like & getrecommendations! Published in 2021 at "Nanomedicine"
DOI: 10.2217/nnm-2021-0180
Abstract: Background: Overexpression of sFlt-1 or modulation of FKBPL, key antiangiogenic proteins, are important in the pathogenesis of preeclampsia. Methods: A newly developed nonviral gene-delivery system, RALA, capable of overexpressing sFlt-1 (e15a isoform) was delivered in… read more here.
Keywords: rala; sflt; preeclampsia; gene delivery ... See more keywords
Elastin-Derived VGVAPG Fragment Decorated Cell-Penetrating Peptide with Improved Gene Delivery Efficacy
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15020670
Abstract: Cell-penetrating peptides (CPPs) are attractive non-viral gene delivery vectors due to their high transfection capacity and safety. Previously, we have shown that cell-penetrating peptide RALA can be a promising gene delivery vector for chronic wound… read more here.
Keywords: cell; cell penetrating; rala; gene delivery ... See more keywords