Photo from wikipedia
Sign Up to like & get
recommendations!
0
Published in 2020 at "Journal of separation science"
DOI: 10.1002/jssc.202000835
Abstract: The aim of this study is to establish a reliable LC-MS method to simultaneously quantitate raloxifene, and its major metabolites, raloxifene-6-glucuronide, raloxifene-4'-glucuronide and raloxifene-6-sulfate in rat plasma samples for pharmacokinetic studies. The separation of the…
read more here.
Keywords:
pharmacokinetic studies;
glucuronide raloxifene;
method;
raloxifene glucuronide ... See more keywords
Photo from wikipedia
Sign Up to like & get
recommendations!
0
Published in 2021 at "Pharmaceutical research"
DOI: 10.1007/s11095-021-03084-y
Abstract: PURPOSE Raloxifene undergoes extensive glucuronidation in the gastrointestinal (GI) tract and the liver. However, the impact of age on raloxifene disposition has never been studied. The purpose of this paper is to determine glucuronidation and…
read more here.
Keywords:
oral bioavailability;
week;
disposition;
age ... See more keywords
Sign Up to like & get
recommendations!
1
Published in 2018 at "American Journal of Obstetrics and Gynecology"
DOI: 10.1016/j.ajog.2018.03.031
Abstract: Background Raloxifene and tamoxifen are Food and Drug Administration–approved for breast cancer risk reduction; in 2013, the US Preventive Services Task Force recommended these drugs for breast cancer risk reduction in high‐risk women. Information on…
read more here.
Keywords:
risk;
use;
breast cancer;
cancer risk ... See more keywords
Sign Up to like & get
recommendations!
0
Published in 2022 at "Experimental eye research"
DOI: 10.1016/j.exer.2022.108966
Abstract: Visual deficits after ocular blast injury (OBI) are common, but pharmacological approaches to improve long-term outcomes have not been identified. Blast forces frequently damage the retina and optic nerves, and work on experimental animals has…
read more here.
Keywords:
raloxifene;
optic nerve;
pathology;
visual deficits ... See more keywords
Photo from wikipedia
Sign Up to like & get
recommendations!
1
Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01125
Abstract: Human aldehyde oxidase (hAOX1) is mainly present in the liver and has an emerging role in drug metabolism, since it accepts a wide range of molecules as substrates and inhibitors. Herein, we employed an integrative…
read more here.
Keywords:
inhibition;
aldehyde oxidase;
ray crystallography;
spectroscopy ... See more keywords
Sign Up to like & get
recommendations!
0
Published in 2018 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.7b01090
Abstract: Phase II biotransformation reactions have been gaining more attention due to their acknowledged significance in drug bioavailability, drug development, and drug-drug interactions. However, the predominant role of phase I metabolism has always overshadowed phase II metabolism, resulting…
read more here.
Keywords:
effect;
nano lipospheres;
phase metabolism;
raloxifene ... See more keywords
Photo from wikipedia
Sign Up to like & get
recommendations!
0
Published in 2020 at "Current Medical Research and Opinion"
DOI: 10.1080/03007995.2020.1816537
Abstract: Abstract Aims We conducted a head-to-head randomized trial of minodronate, a bisphosphonate, and raloxifene, a selective estrogen receptor modulator, to obtain clinical evidence and information about their efficacy and safety. Methods The Japanese Osteoporosis Intervention…
read more here.
Keywords:
incidence;
japanese osteoporosis;
trial;
head head ... See more keywords
Sign Up to like & get
recommendations!
0
Published in 2017 at "British Journal of Pharmacology"
DOI: 10.1111/bph.13733
Abstract: Raloxifene can induce both endothelium‐dependent and ‐independent relaxation in different arteries. However, the underlying mechanisms by which raloxifene triggers endothelium‐independent relaxation are still incompletely understood. The purpose of present study was to examine the roles…
read more here.
Keywords:
raloxifene rat;
independent relaxation;
endothelium independent;
raloxifene ... See more keywords
Photo from wikipedia
Sign Up to like & get
recommendations!
1
Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10040853
Abstract: Androgen receptor (AR)-castrate-resistant prostate cancer (CRPC) is an aggressive form of prostate cancer that does not have clinically approved targeted treatment options. To this end, the cytotoxic potential of raloxifene and the synthetic curcumin derivative…
read more here.
Keywords:
prostate cancer;
prostate;
resistant prostate;
raloxifene ... See more keywords
Photo by nci from unsplash
Sign Up to like & get
recommendations!
1
Published in 2023 at "Cancers"
DOI: 10.3390/cancers15020456
Abstract: Simple Summary Pancreatic cancer is presently the fourth most common cause of cancer-related death. Treatment options and prognosis are poor. Therefore, new therapeutic approaches are urgently needed. Molecular targeting of the interleukin-6/glycoprotein-130/signal transducer and activator…
read more here.
Keywords:
pancreatic cancer;
raloxifene;
glycoprotein 130;
paclitaxel ... See more keywords
Photo from wikipedia
Sign Up to like & get
recommendations!
2
Published in 2023 at "Pharmaceuticals"
DOI: 10.3390/ph16020222
Abstract: Both osteoporosis and cardiovascular disease (CVD) share similar pathways in pathophysiology and are intercorrelated with increased morbidity and mortality in elderly women. Although denosumab and raloxifene are the current guideline-based pharmacological treatments, their impacts on…
read more here.
Keywords:
raloxifene;
group;
mortality;
denosumab superior ... See more keywords