Development and validation of ultra-high-performance liquid chromatography-MS method for the determination of raloxifene and its phase II metabolites in plasma: Application to pharmacokinetic studies in rats.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of separation science"
DOI: 10.1002/jssc.202000835
Abstract: The aim of this study is to establish a reliable LC-MS method to simultaneously quantitate raloxifene, and its major metabolites, raloxifene-6-glucuronide, raloxifene-4'-glucuronide and raloxifene-6-sulfate in rat plasma samples for pharmacokinetic studies. The separation of the… read more here.
Keywords: pharmacokinetic studies; glucuronide raloxifene; method; raloxifene glucuronide ... See more keywords
Age-and Region-Dependent Disposition of Raloxifene in Rats.
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceutical research"
DOI: 10.1007/s11095-021-03084-y
Abstract: PURPOSE Raloxifene undergoes extensive glucuronidation in the gastrointestinal (GI) tract and the liver. However, the impact of age on raloxifene disposition has never been studied. The purpose of this paper is to determine glucuronidation and… read more here.
Keywords: oral bioavailability; week; disposition; age ... See more keywords
Use of raloxifene and tamoxifen by breast cancer risk level in a Medicare‐eligible cohort
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Obstetrics and Gynecology"
DOI: 10.1016/j.ajog.2018.03.031
Abstract: Background Raloxifene and tamoxifen are Food and Drug Administration–approved for breast cancer risk reduction; in 2013, the US Preventive Services Task Force recommended these drugs for breast cancer risk reduction in high‐risk women. Information on… read more here.
Keywords: risk; use; breast cancer; cancer risk ... See more keywords
Raloxifene, a cannabinoid type-2 receptor inverse agonist, mitigates visual deficits and pathology and modulates microglia after ocular blast.
Sign Up to like & getrecommendations! Published in 2022 at "Experimental eye research"
DOI: 10.1016/j.exer.2022.108966
Abstract: Visual deficits after ocular blast injury (OBI) are common, but pharmacological approaches to improve long-term outcomes have not been identified. Blast forces frequently damage the retina and optic nerves, and work on experimental animals has… read more here.
Keywords: raloxifene; optic nerve; pathology; visual deficits ... See more keywords
Interrogating the Inhibition Mechanisms of Human Aldehyde Oxidase by X-ray Crystallography and NMR Spectroscopy: The Raloxifene Case.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01125
Abstract: Human aldehyde oxidase (hAOX1) is mainly present in the liver and has an emerging role in drug metabolism, since it accepts a wide range of molecules as substrates and inhibitors. Herein, we employed an integrative… read more here.
Keywords: inhibition; aldehyde oxidase; ray crystallography; spectroscopy ... See more keywords
The Effect of Piperine Pro-Nano Lipospheres on Direct Intestinal Phase II Metabolism: The Raloxifene Paradigm of Enhanced Oral Bioavailability.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.7b01090
Abstract: Phase II biotransformation reactions have been gaining more attention due to their acknowledged significance in drug bioavailability, drug development, and drug-drug interactions. However, the predominant role of phase I metabolism has always overshadowed phase II metabolism, resulting… read more here.
Keywords: effect; nano lipospheres; phase metabolism; raloxifene ... See more keywords
Randomized head-to-head comparison of minodronic acid and raloxifene for fracture incidence in postmenopausal Japanese women: the Japanese Osteoporosis Intervention Trial (JOINT)-04
Sign Up to like & getrecommendations! Published in 2020 at "Current Medical Research and Opinion"
DOI: 10.1080/03007995.2020.1816537
Abstract: Abstract Aims We conducted a head-to-head randomized trial of minodronate, a bisphosphonate, and raloxifene, a selective estrogen receptor modulator, to obtain clinical evidence and information about their efficacy and safety. Methods The Japanese Osteoporosis Intervention… read more here.
Keywords: incidence; japanese osteoporosis; trial; head head ... See more keywords
Role of inducible nitric oxide synthase in endothelium‐independent relaxation to raloxifene in rat aorta
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Pharmacology"
DOI: 10.1111/bph.13733
Abstract: Raloxifene can induce both endothelium‐dependent and ‐independent relaxation in different arteries. However, the underlying mechanisms by which raloxifene triggers endothelium‐independent relaxation are still incompletely understood. The purpose of present study was to examine the roles… read more here.
Keywords: raloxifene rat; independent relaxation; endothelium independent; raloxifene ... See more keywords
Raloxifene Suppresses Tumor Growth and Metastasis in an Orthotopic Model of Castration-Resistant Prostate Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10040853
Abstract: Androgen receptor (AR)-castrate-resistant prostate cancer (CRPC) is an aggressive form of prostate cancer that does not have clinically approved targeted treatment options. To this end, the cytotoxic potential of raloxifene and the synthetic curcumin derivative… read more here.
Keywords: prostate cancer; prostate; resistant prostate; raloxifene ... See more keywords
Targeting Interleukin-6/Glycoprotein-130 Signaling by Raloxifene or SC144 Enhances Paclitaxel Efficacy in Pancreatic Cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15020456
Abstract: Simple Summary Pancreatic cancer is presently the fourth most common cause of cancer-related death. Treatment options and prognosis are poor. Therefore, new therapeutic approaches are urgently needed. Molecular targeting of the interleukin-6/glycoprotein-130/signal transducer and activator… read more here.
Keywords: pancreatic cancer; raloxifene; glycoprotein 130; paclitaxel ... See more keywords
Denosumab Is Superior to Raloxifene in Lowering Risks of Mortality and Ischemic Stroke in Osteoporotic Women
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceuticals"
DOI: 10.3390/ph16020222
Abstract: Both osteoporosis and cardiovascular disease (CVD) share similar pathways in pathophysiology and are intercorrelated with increased morbidity and mortality in elderly women. Although denosumab and raloxifene are the current guideline-based pharmacological treatments, their impacts on… read more here.
Keywords: raloxifene; group; mortality; denosumab superior ... See more keywords