In Vivo Evaluation of Novel Geranylgeranyl Diphosphate Synthase Inhibitors
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DOI: 10.1182/blood-2018-99-113007
Abstract: The enzyme geranylgeranyl diphosphate synthase (GGDPS) synthesizes the 20-carbon isoprenoid geranylgeranyl diphosphate which is used in protein geranylgeranylation reactions. Our work has demonstrated that GGDPS inhibitors (GGDPSIs) represent a novel therapeutic strategy for multiple myeloma… read more here.
Keywords: ram2061; geranylgeranyl diphosphate; ram2061 ram2093; geranylgeranylation ... See more keywords