Computational Analysis of the Molecular Mechanism of RamR Mutations Contributing to Antimicrobial Resistance in Salmonella enterica
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DOI: 10.1038/s41598-017-14008-5
Abstract: Antimicrobial resistance (AMR) in pathogenic microorganisms with multidrug resistance (MDR) constitutes a severe threat to human health. A major causative mechanism of AMR is mediated through the multidrug efflux pump (MEP). The resistance-nodulation-division superfamily (RND… read more here.
Keywords: mechanism; antimicrobial resistance; resistance; rama ... See more keywords
Serratia marcescens RamA Expression Is under PhoP-Dependent Control and Modulates Lipid A-Related Gene Transcription and Antibiotic Resistance Phenotypes
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DOI: 10.1128/jb.00523-20
Abstract: We demonstrate that in S. marcescens, the transcriptional regulator RamA is autoregulated and also controlled by the PhoP/PhoQ signal transduction system. We have shown that PhoP is able to directly and specifically bind to ramA,… read more here.
Keywords: lpxo2; rama; phop phoq; marcescens rama ... See more keywords