Terminal Alkynes as Raman Probes of α‐Synuclein in Solution and in Cells
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DOI: 10.1002/cbic.202000026
Abstract: Conformational changes in α‐synuclein (α‐syn) are central to its biological function and Parkinson's disease pathology. Here, terminal alkynes (homopropargylglycine) were employed as environmentally sensitive Raman probes at residues 1, 5, 116, and 127 to characterize… read more here.
Keywords: solution cells; terminal alkynes; probes synuclein; raman probes ... See more keywords
Multicolor Activatable Raman Probes for Simultaneous Detection of Plural Enzyme Activities.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.0c09200
Abstract: Raman probes based on alkyne or nitrile tags hold promise for highly multiplexed imaging. However, sensing of enzyme activities with Raman probes is difficult because few mechanisms are available to modulate the vibrational response. Here… read more here.
Keywords: raman; enzyme activities; raman probes; activatable raman ... See more keywords