Three‐Step Total Synthesis of Ramelteon via a Catellani Strategy
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DOI: 10.1002/cctc.201901355
Abstract: Ramelteon is the first medicine in human history that treat insomnia as a melatonin receptor agonist. Herein, we report an efficient three‐step synthetic route to access it from commercially available 2,3‐dihydrobenzofuran‐4‐amine, which represents as the… read more here.
Keywords: three step; catellani; ramelteon; step total ... See more keywords
Postoperative delirium after pharyngolaryngectomy with esophagectomy: a role for ramelteon and suvorexant
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DOI: 10.1007/s10388-017-0570-z
Abstract: BackgroundPostoperative delirium is common after extensive surgery, and is known to be associated with sleeping medications. In this study, we aimed to investigate the relationships between sleeping medications and postoperative delirium after pharyngolaryngectomy with esophagectomy.MethodsWe… read more here.
Keywords: pharyngolaryngectomy esophagectomy; delirium; ramelteon; delirium pharyngolaryngectomy ... See more keywords
Ramelteon protects against human pulmonary microvascular endothelial cell injury induced by lipopolysaccharide (LPS) via activating nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2021.2021065
Abstract: ABSTRACT Acute lung injury (ALI) is classified as a moderate or mild acute respiratory distress syndrome and is a prominent cause of morbidity and mortality among the critically ill population. Ramelteon is a melatonin receptor… read more here.
Keywords: hpmecs; cell; ramelteon; factor ... See more keywords
From One-Size-Fits-All to Mechanism-Guided Treatment for Intracranial Hemorrhage.
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DOI: 10.1097/ccm.0000000000004055
Abstract: Critical Care Medicine www.ccmjournal.org 1815 4. Pandharipande P, Shintani A, Peterson J, et al: Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients. Anesthesiology 2006; 104:21–26 5. Kolla BP,… read more here.
Keywords: care; medicine; melatonin; ramelteon ... See more keywords
Ramelteon for delirium prevention in hospitalized patients: An updated meta‐analysis and trial sequential analysis of randomized controlled trials
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DOI: 10.1111/jpi.12857
Abstract: Although ramelteon has been examined as a relatively new therapeutic option for delirium prevention, current evidence to evaluate its efficacy is limited. We conducted an updated meta‐analysis and examine the reliability of existing evidence regarding… read more here.
Keywords: meta analysis; ramelteon; delirium prevention; delirium ... See more keywords
Effectiveness of ramelteon for residual sleep disturbances (hypersomnia) in a patient with premenstrual dysphoric disorder
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DOI: 10.1111/pcn.12484
Abstract: O NE OF THE characteristic symptoms of premenstrual dysphoric disorder (PMDD) is sleep disturbance before menstruation, mainly involving hypersomnia, and insomnia can occur in some cases. In most PMDD patients, the administration of selective serotonin… read more here.
Keywords: ramelteon; sleep disturbances; nocturnal awakenings; disturbances hypersomnia ... See more keywords
Ramelteon in the Treatment of Delirium: New Perspectives from Reported Findings and a Case Observation
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DOI: 10.2174/1574885514666190308161421
Abstract: Ramelteon is a melatonin receptor agonist that is approved for the treatment of insomnia. It is widely used due to its relatively benign side effect profile and lack of dependence or withdrawal. Due to its… read more here.
Keywords: ramelteon treatment; ramelteon; treatment; treatment delirium ... See more keywords
Ramelteon Reduces Oxidative Stress by Maintenance of Lipid Homeostasis in Porcine Oocytes
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DOI: 10.3390/antiox11091640
Abstract: This study aimed to determine the underlying mechanism of ramelteon on the competence of oocyte and subsequent embryo development in pigs during in vitro maturation (IVM). Our results showed that the cumulus expansion index was… read more here.
Keywords: ramelteon; development; compared control; oxidative stress ... See more keywords