Negative allosteric modulation of the glucagon receptor by RAMP2
Sign Up to like & getrecommendations! Published in 2022 at "Cell"
DOI: 10.1101/2022.08.30.505955
Abstract: Receptor activity-modifying proteins (RAMPs) modulate the activity of many Family B heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors (GPCRs). The glucagon receptor (GCGR), a Family B GPCR responsible for maintenance of proper blood sugar levels,… read more here.
Keywords: gcgr; ramp2; receptor; negative allosteric ... See more keywords
RAMP2 Influences Glucagon Receptor Pharmacology via Trafficking and Signaling
Sign Up to like & getrecommendations! Published in 2017 at "Endocrinology"
DOI: 10.1210/en.2016-1755
Abstract: Endogenous satiety hormones provide an attractive target for obesity drugs. Glucagon causes weight loss by reducing food intake and increasing energy expenditure. To further understand the cellular mechanisms by which glucagon and related ligands activate… read more here.
Keywords: gcgr; microscopy; ramp2; glucagon receptor ... See more keywords