Inhibition of Cell Cycle Progression, Induction of Apoptosis, and Changes in Surface Markers of MEG-01 Megakaryoblastic Cells Exposed to a Random Positioning Machine
Sign Up to like & getrecommendations! Published in 2019 at "Microgravity Science and Technology"
DOI: 10.1007/s12217-019-09737-3
Abstract: One cause of thrombocytopenia in astronauts after spaceflight is decreased platelet production. To increase our understanding of thrombopoiesis in humans while in space, we investigated the effects of simulated microgravity, achieved using a random positioning… read more here.
Keywords: random positioning; simulated microgravity; cell cycle; cell ... See more keywords
Theoretical study on microgravity and hypogravity simulated by random positioning machine
Sign Up to like & getrecommendations! Published in 2020 at "Acta Astronautica"
DOI: 10.1016/j.actaastro.2020.07.047
Abstract: Abstract The random positioning machine (RPM), which continuously changes the gravity direction acting on a subject, can provide the simulated microgravity and planet hypogravity environments to the bioreactor on Earth. In this study, a theoretical… read more here.
Keywords: positioning machine; random positioning; rpm; hypogravity ... See more keywords
Pyrocystis noctiluca represents an excellent bioassay for shear forces induced in ground-based microgravity simulators (clinostat and random positioning machine)
Sign Up to like & getrecommendations! Published in 2017 at "NPJ Microgravity"
DOI: 10.1038/s41526-017-0016-x
Abstract: Ground-based facilities, such as clinostats and random positioning machines aiming at simulating microgravity conditions, are tools to prepare space experiments and identify gravity-related signaling pathways. A prerequisite is that the facilities are operated in an… read more here.
Keywords: positioning machine; random positioning; ground based; shear forces ... See more keywords
Dexamethasone Selectively Inhibits Detachment of Metastatic Thyroid Cancer Cells during Random Positioning
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15061641
Abstract: Simple Summary Metastasis is the most dangerous feature of advanced cancers. In vitro models of this process could help us to study and understand mechanisms that are not readily accessible in the human body. In… read more here.
Keywords: thyroid; metastatic thyroid; thyroid cancer; random positioning ... See more keywords
Biological and Mechanical Characterization of the Random Positioning Machine (RPM) for Microgravity Simulations
Sign Up to like & getrecommendations! Published in 2021 at "Life"
DOI: 10.3390/life11111190
Abstract: The rapid improvement of space technologies is leading to the continuous increase of space missions that will soon bring humans back to the Moon and, in the coming future, toward longer interplanetary missions such as… read more here.
Keywords: positioning machine; random positioning; space; biological mechanical ... See more keywords