A randomised clinical trial of methotrexate points to possible efficacy and adaptive immune dysfunction in psychosis
Sign Up to like & getrecommendations! Published in 2020 at "Translational Psychiatry"
DOI: 10.1038/s41398-020-01095-8
Abstract: NMDA autoantibody encephalitis presenting as schizophrenia suggests the possible role of adaptive cell-mediated immunity in idiopathic schizophrenia. However, to our knowledge there have been no trials of the immune-suppressant methotrexate in schizophrenia. We tested if… read more here.
Keywords: randomised clinical; trial methotrexate; clinical trial; points possible ... See more keywords
Effects of a 12-week Vivifrail exercise program on intrinsic capacity among frail cognitively impaired community-dwelling older adults: secondary analysis of a multicentre randomised clinical trial
Sign Up to like & getrecommendations! Published in 2022 at "Age and Ageing"
DOI: 10.1093/ageing/afac303
Abstract: Abstract Introduction The World Health Organisation recently defined the construct of intrinsic capacity (IC), a function-based marker of older adult’s health encompassing all mental and physical capacities of the individual. Multicomponent physical exercise (MCE) is… read more here.
Keywords: older adults; randomised clinical; intrinsic capacity; cognitively impaired ... See more keywords
O-095 Is the process to retract fabricated randomised clinical trials in reproductive medicine working sufficiently?
Sign Up to like & getrecommendations! Published in 2021 at "Human Reproduction"
DOI: 10.1093/humrep/deab125.031
Abstract: How do journal editors and publishers respond on randomised clinical trials in reproductive medicine that have been identified as fabricated? Despite clear proof of fabrication, only a small minority of fabricated RCTs is retracted within… read more here.
Keywords: medicine; randomised clinical; reproductive medicine; process ... See more keywords
Treatment for acute uncomplicated diverticulitis without antibiotherapy: systematic review and meta-analysis of randomised clinical trials.
Sign Up to like & getrecommendations! Published in 2023 at "International journal of surgery"
DOI: 10.1097/js9.0000000000000307
Abstract: BACKGROUND Use of antibiotics in selected cases of acute uncomplicated diverticulitis (AUD) has recently been questioned. OBJECTIVE The aim of this study is to examine the safety and efficacy of treatment regimens without antibiotics compared… read more here.
Keywords: clinical trials; randomised clinical; review; diverticulitis ... See more keywords
Prompt closure versus gradual weaning of external ventricular drainage for hydrocephalus following aneurysmal subarachnoid haemorrhage: Protocol for the DRAIN randomised clinical trial.
Sign Up to like & getrecommendations! Published in 2023 at "Acta anaesthesiologica Scandinavica"
DOI: 10.1111/aas.14263
Abstract: BACKGROUND Aneurysmal subarachnoid haemorrhage (aSAH) is a life-threatening disease caused by rupture of an intracranial aneurysm. A common complication following aSAH is hydrocephalus, for which placement of an external ventricular drain (EVD) is an important… read more here.
Keywords: randomised clinical; clinical trial; prompt closure; gradual weaning ... See more keywords
Comment on ‘Comparison of losartan and amlodipine effects on the outcomes of patient with COVID‐19 and primary hypertension: A randomised clinical trial’
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Clinical Practice"
DOI: 10.1111/ijcp.14957
Abstract: 1. The aim of their study was to compare, using a randomised clinical trial in hospitalised patients with COVID19 and primary hypertension, the effects of losartan and amlodipine using two primary outcomes: 30day mortality and… read more here.
Keywords: study; randomised clinical; amlodipine; mortality ... See more keywords
Assessment of assumptions of statistical analysis methods in randomised clinical trials: the what and how
Sign Up to like & getrecommendations! Published in 2020 at "BMJ Evidence-Based Medicine"
DOI: 10.1136/bmjebm-2019-111268
Abstract: When analysing and presenting results of randomised clinical trials, trialists rarely report if or how underlying statistical assumptions were validated. To avoid data-driven biased trial results, it should be common practice to prospectively describe the… read more here.
Keywords: randomised clinical; regression; underlying assumptions; clinical trials ... See more keywords
Vascular and cognitive effects of cocoa-rich chocolate in postmenopausal women: a study protocol for a randomised clinical trial
Sign Up to like & getrecommendations! Published in 2018 at "BMJ Open"
DOI: 10.1136/bmjopen-2018-024095
Abstract: Introduction The intake of polyphenols has certain health benefits. This study will aim to assess the effect of adding a daily amount of chocolate high in cocoa content and polyphenols to the normal diet on… read more here.
Keywords: clinical trial; randomised clinical; trial; chocolate ... See more keywords
Protocol for a randomised clinical trial of multimodal postconcussion symptom treatment and recovery: the Concussion Essentials study
Sign Up to like & getrecommendations! Published in 2021 at "BMJ Open"
DOI: 10.1136/bmjopen-2020-041458
Abstract: Introduction While most children recover from a concussion shortly after injury, approximately 30% experience persistent postconcussive symptoms (pPCS) beyond 1-month postinjury. Existing research into the treatment of pPCS have evaluated unimodal approaches, despite evidence suggesting… read more here.
Keywords: randomised clinical; clinical trial; symptom; treatment ... See more keywords
Involving patients and clinicians in a pilot randomised clinical trial of spinal manual therapy versus nerve root injection for lumbar radiculopathy: protocol of a patient and public involvement project
Sign Up to like & getrecommendations! Published in 2022 at "BMJ Open"
DOI: 10.1136/bmjopen-2021-057881
Abstract: Introduction A patient and public involvement (PPI) project will be embedded within the SALuBRITY pilot trial, a two parallel group, double sham controlled, randomised clinical trial. The study aims to compare the effectiveness of spinal… read more here.
Keywords: public involvement; lumbar radiculopathy; randomised clinical; trial ... See more keywords
Registry-based randomised clinical trial: efficient evaluation of generic pharmacotherapies in the contemporary era
Sign Up to like & getrecommendations! Published in 2018 at "Heart"
DOI: 10.1136/heartjnl-2017-312322
Abstract: Randomised clinical trials are the gold standard for testing the effectiveness of clinical interventions. However, increasing complexity and associated costs may limit their application in the investigation of key cardiovascular knowledge gaps such as the… read more here.
Keywords: randomised clinical; trial; based randomised; generic pharmacotherapies ... See more keywords