Repeated 5-day cycles of low dose aldesleukin in amyotrophic lateral sclerosis (IMODALS): A phase 2a randomised, double-blind, placebo-controlled trial
Sign Up to like & getrecommendations! Published in 2020 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2020.102844
Abstract: Background Low-dose interleukin-2 (ld-IL-2) enhances regulatory T-cell (Treg) function in auto-inflammatory conditions. Neuroinflammation being a pathogenic feature of amyotrophic lateral sclerosis (ALS), we evaluated the pharmacodynamics and safety of ld-IL-2 in ALS subjects. Methods We… read more here.
Keywords: low dose; randomised double; miu; amyotrophic lateral ... See more keywords
Effects of a Bacopa monnieri extract (Bacognize®) on stress, fatigue, quality of life and sleep in adults with self-reported poor sleep: A randomised, double-blind, placebo-controlled study
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2021.104671
Abstract: Abstract In this 28-day, randomised, double-blind, placebo-controlled trial, 100 adults with self-reported poor sleep received either a placebo or a standardised Bacopa monnieri extract (150 mg twice daily). Outcome measures included the Bergen Insomnia Scale (primary… read more here.
Keywords: randomised double; bacopa monnieri; sleep; double blind ... See more keywords
Cariprazine versus risperidone monotherapy for treatment of predominant negative symptoms in patients with schizophrenia: a randomised, double-blind, controlled trial
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DOI: 10.1016/s0140-6736(17)30060-0
Abstract: BACKGROUND Although predominant negative symptoms of schizophrenia can be severe enough to cause persistent impairment, effective treatment options are lacking. We aimed to assess the new generation antipsychotic cariprazine in adult patients with predominant negative… read more here.
Keywords: randomised double; negative symptoms; treatment; predominant negative ... See more keywords
Dietary strawberry improves cognition in a randomised, double-blind, placebo-controlled trial in older adults
Sign Up to like & getrecommendations! Published in 2021 at "British Journal of Nutrition"
DOI: 10.1017/s0007114521000222
Abstract: Abstract Functional changes in the brain during ageing can alter learning and memory, gait and balance – in some cases leading to early cognitive decline, disability or injurious falls among older adults. Dietary interventions with… read more here.
Keywords: randomised double; placebo; double blind; older adults ... See more keywords
Multispecies probiotic administration reduces emotional salience and improves mood in subjects with moderate depression: a randomised, double-blind, placebo-controlled study.
Sign Up to like & getrecommendations! Published in 2022 at "Psychological medicine"
DOI: 10.1017/s003329172100550x
Abstract: BACKGROUND The potential antidepressant properties of probiotics have been suggested, but their influence on the emotional processes that may underlie this effect is unclear. METHODS Depressed volunteers (n = 71) were recruited into a randomised… read more here.
Keywords: randomised double; multispecies probiotic; controlled study; double blind ... See more keywords
Effect of whole soy and purified daidzein on androgenic hormones in chinese equol-producing post-menopausal women: a six-month randomised, double-blinded and Placebo-Controlled trial
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Food Sciences and Nutrition"
DOI: 10.1080/09637486.2020.1712682
Abstract: Abstract A randomised, double-blind and placebo-controlled trial was performed to examine the effects of whole soy and isoflavone daidzein on serum androgenic hormones in Chinese equol-producing post-menopausal women. A total of 270 eligible women aged… read more here.
Keywords: trial; randomised double; whole soy; placebo ... See more keywords
THU0516 Efficacy and safety of vitamin d3 in patients with fibromyalgia. randomised, double blind, placebo-controlled trial
Sign Up to like & getrecommendations! Published in 2018 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-eular.6541
Abstract: Background fibromyalgia (FM) is a disease characterised by widespread pain, sometimes fatigue, memory problems and sleep disturbances. It has been suggested that low blood levels of vitamin D correlate with increased pain scores in patients… read more here.
Keywords: randomised double; efficacy safety; safety vitamin; placebo ... See more keywords
Antiviral therapy: Valacyclovir Treatment of Alzheimer’s Disease (VALAD) Trial: protocol for a randomised, double-blind, placebo-controlled, treatment trial
Sign Up to like & getrecommendations! Published in 2020 at "BMJ Open"
DOI: 10.1136/bmjopen-2019-032112
Abstract: Introduction After infection, herpes simplex virus-1 (HSV1) becomes latent in the trigeminal ganglion and can enter the brain via retrograde axonal transport. Recurrent reactivation of HSV1 may lead to neurodegeneration and Alzheimer’s disease (AD) pathology.… read more here.
Keywords: trial; randomised double; alzheimer disease; treatment ... See more keywords
Biofortification of wheat with zinc for eliminating deficiency in Pakistan: study protocol for a cluster-randomised, double-blind, controlled effectiveness study (BIZIFED2)
Sign Up to like & getrecommendations! Published in 2020 at "BMJ Open"
DOI: 10.1136/bmjopen-2020-039231
Abstract: Introduction Micronutrient deficiencies, commonly referred to as ‘hidden hunger’, affect more than two billion people worldwide, with zinc and iron-deficiency frequently reported. The aim of this study is to examine the impact of consuming zinc… read more here.
Keywords: randomised double; zinc; cluster randomised; study ... See more keywords
Atorvastatin for unruptured intracranial vertebrobasilar dissecting aneurysm (ATREAT-VBD): protocol for a randomised, double-blind, blank-controlled trial
Sign Up to like & getrecommendations! Published in 2022 at "BMJ Open"
DOI: 10.1136/bmjopen-2021-059616
Abstract: Introduction Vertebrobasilar dissecting aneurysms (VBDAs) are associated with serious complications and a poor prognosis. It is believed that inflammation of the aneurysm wall may be the main cause of rupture or deterioration. Atorvastatin has been… read more here.
Keywords: randomised double; trial; vertebrobasilar dissecting; double blind ... See more keywords
The Effect of a Dispersible Curcumin (HydroCurc®) Compared to a Placebo for Reducing Joint Pain in an Adult Population – A Randomised, Double-Blind Study
Sign Up to like & getrecommendations! Published in 2022 at "Complementary Medicine Research"
DOI: 10.1159/000524689
Abstract: Introduction: This study aimed to assess the efficacy of a novel curcumin formulation, HydroCurc®, for alleviating joint pain and improving quality of life in adults. Method: A randomised, double blind, placebo-controlled study was conducted on… read more here.
Keywords: joint pain; randomised double; curcumin; double blind ... See more keywords