An empirical investigation into the impact of winner's curse on estimates from Mendelian randomization
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DOI: 10.1101/2022.08.05.22278470
Abstract: Introduction: Genetic associations for variants identified through genome-wide association studies (GWAS) tend to be overestimated in the original discovery dataset; as if the association was underestimated, the variant may not have been detected. This bias,… read more here.
Keywords: mendelian randomization; impact; winner curse; randomization estimates ... See more keywords