Women's reproductive traits and ischemic stroke: a two‐sample Mendelian randomization study
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51702
Abstract: We conducted a Mendelian randomization (MR) study to disentangle causal associations between women's reproductive behaviors and ischemic stroke (IS) and investigate the roles of two modifiable risk factors (body mass index (BMI) and educational attainment… read more here.
Keywords: women reproductive; mendelian randomization; randomization study; ischemic stroke ... See more keywords
Metabolomic Pathways to Osteoporosis in Middle‐Aged Women: A Genome‐Metabolome‐Wide Mendelian Randomization Study
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.3358
Abstract: The metabolic state of the body can be a major determinant of bone health. We used a Mendelian randomization approach to identify metabolites causally associated with bone mass to better understand the biological mechanisms of… read more here.
Keywords: bone; randomization study; bone mineral; mendelian randomization ... See more keywords
An atlas on risk factors for multiple sclerosis: a Mendelian randomization study
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neurology"
DOI: 10.1007/s00415-020-10119-8
Abstract: Objectives We conducted a systematic review and wide-angled Mendelian randomization (MR) study to examine the association between possible risk factors and multiple sclerosis (MS). Methods We used MR analysis to assess the associations between 65… read more here.
Keywords: randomization study; risk; mendelian randomization; factors multiple ... See more keywords
Genetically rheumatoid arthrits and risk of comorbidities: a Mendelian randomization study
Sign Up to like & getrecommendations! Published in 2020 at "European Heart Journal"
DOI: 10.1093/ehjci/ehaa946.3152
Abstract: Ample observational evidence indicates that patients with rheumatoid arthritis (RA) are at increased risk of developing comorbid conditions, in particular cardiovascular disease. The pathogenesis of these comorbidities is still largely unknown. For effective preventive measures,… read more here.
Keywords: randomization study; risk; randomization; mendelian randomization ... See more keywords
Causal associations of serum matrix metalloproteinase‐8 level with ischaemic stroke and ischaemic stroke subtypes: a Mendelian randomization study
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Neurology"
DOI: 10.1111/ene.14878
Abstract: Elevated serum matrix metalloproteinase‐8 (MMP‐8) concentrations are associated with high risk of vascular disease, but the causality remains unclear. A two‐sample Mendelian randomization (MR) study was performed to examine the causal effect of serum MMP‐8… read more here.
Keywords: randomization study; matrix metalloproteinase; mendelian randomization; serum matrix ... See more keywords
Circulating vitamin C and D concentrations and risk of dental caries and periodontitis: A Mendelian randomization study.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of clinical periodontology"
DOI: 10.1111/jcpe.13598
Abstract: AIM This Mendelian randomization (MR) study was performed to explore the causal relationship among circulating vitamin C and D levels, dental caries, and periodontitis. MATERIALS AND METHODS MR analyses were conducted with the inverse-variance-weighted (IVW)… read more here.
Keywords: mendelian randomization; vitamin concentrations; dental caries; randomization study ... See more keywords
Association between inflammatory bowel disease and periodontitis: A bidirectional 2-Sample Mendelian randomization study.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of clinical periodontology"
DOI: 10.1111/jcpe.13782
Abstract: AIM This Mendelian randomization (MR) study was performed to explore the potential bidirectional causal association between inflammatory bowel disease (IBD) and periodontitis. MATERIALS AND METHODS We used genetic instruments from the genome-wide association study (GWAS)… read more here.
Keywords: disease; mendelian randomization; periodontitis; randomization study ... See more keywords
Effects of Adiponectin on T2DM and Glucose Homeostasis: A Mendelian Randomization Study
Sign Up to like & getrecommendations! Published in 2020 at "Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy"
DOI: 10.2147/dmso.s248352
Abstract: Purpose The associations of adiponectin with type 2 diabetes mellitus (T2DM), glucose homeostasis (including β-cell function index (HOMA-β), insulin resistance (HOMA-IR), fasting insulin (FI) and fasting glucose (FG)) have reported in epidemiological studies. However, the… read more here.
Keywords: mendelian randomization; randomization study; t2dm glucose; glucose homeostasis ... See more keywords
Effects of steroid hormones on lipid metabolism in sexual dimorphism: A Mendelian randomization study
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.1119154
Abstract: Background Although the role of steroid hormones in lipid levels has been partly discussed in the context of separate sexes, the causal relationship between steroid hormones and lipid metabolism according to sex has not been… read more here.
Keywords: mendelian randomization; lipid metabolism; steroid hormones; hormones lipid ... See more keywords
Circulating α-Klotho Levels in Relation to Cardiovascular Diseases: A Mendelian Randomization Study
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.842846
Abstract: Background Several studies have reported a protective role of circulating α-Klotho on cardiovascular diseases (CVD); however, the causality remains unclear. We aim to elucidate whether genetically predicted circulating α-Klotho levels were causally associated with the… read more here.
Keywords: mendelian randomization; cardiovascular diseases; klotho; randomization study ... See more keywords
Intelligence, education level, and risk of Parkinson’s disease in European populations: A Mendelian randomization study
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.963163
Abstract: Background: A high level of education or intelligence (IQ) is reported to be a risk factor for Parkinson’s disease (PD). The purpose of this study was to systematically examine the causal relationships between IQ, educational… read more here.
Keywords: mendelian randomization; parkinson disease; education; risk ... See more keywords