Women's reproductive traits and ischemic stroke: a two‐sample Mendelian randomization study
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DOI: 10.1002/acn3.51702
Abstract: We conducted a Mendelian randomization (MR) study to disentangle causal associations between women's reproductive behaviors and ischemic stroke (IS) and investigate the roles of two modifiable risk factors (body mass index (BMI) and educational attainment… read more here.
Keywords: women reproductive; mendelian randomization; randomization study; ischemic stroke ... See more keywords
Mendelian randomization study of lipid metabolism characteristics and migraine risk
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DOI: 10.1002/ejp.2235
Abstract: The association between serum lipids and migraine is controversial. However, randomized controlled trials have suggested that statins may be efficacious for the prevention of migraine. In this study, we aim to investigate the relationship between… read more here.
Keywords: migraine risk; randomization study; metabolism; mendelian randomization ... See more keywords
Metabolomic Pathways to Osteoporosis in Middle‐Aged Women: A Genome‐Metabolome‐Wide Mendelian Randomization Study
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.3358
Abstract: The metabolic state of the body can be a major determinant of bone health. We used a Mendelian randomization approach to identify metabolites causally associated with bone mass to better understand the biological mechanisms of… read more here.
Keywords: bone; randomization study; bone mineral; mendelian randomization ... See more keywords
An atlas on risk factors for multiple sclerosis: a Mendelian randomization study
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neurology"
DOI: 10.1007/s00415-020-10119-8
Abstract: Objectives We conducted a systematic review and wide-angled Mendelian randomization (MR) study to examine the association between possible risk factors and multiple sclerosis (MS). Methods We used MR analysis to assess the associations between 65… read more here.
Keywords: randomization study; risk; mendelian randomization; factors multiple ... See more keywords
Exploring the causal relationship between B lymphocytes and Parkinson’s disease: a bidirectional, two-sample Mendelian randomization study
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DOI: 10.1038/s41598-024-53287-7
Abstract: Parkinson’s disease (PD) is a neurodegenerative disorder with extensive involvement of motor symptoms, imposing a heavy economic burden on patients and society. B lymphocytes, a group of immune cells associated with humoral immunity, have been… read more here.
Keywords: randomization study; cell; causal relationship; mendelian randomization ... See more keywords
Allergic diseases and T2DM: a bidirectional multivariable Mendelian randomization study and mediation analysis
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Asthma"
DOI: 10.1080/02770903.2024.2430368
Abstract: Abstract Background Clinical studies involving observation have uncovered a mutual relationship between allergic disorders and diabetes, yet the precise causal link remains undetermined. Methods We conducted two-sample bidirectional Mendelian randomization analyses using single nucleotide polymorphisms… read more here.
Keywords: randomization study; type; type diabetes; mendelian randomization ... See more keywords
Genetic prediction of the relationship between mitochondrial proteins and diabetic polyneuropathy risk: a Mendelian randomization study
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DOI: 10.1080/07435800.2025.2557991
Abstract: ABSTRACT Background This Mendelian Randomization (MR) study investigates the causal relationships between mitochondrial proteins and Diabetic polyneuropathy (DPN). Methods Using a two-sample MR design with data from FINNGEN (1048 DPN cases, 374,434 controls) and 63… read more here.
Keywords: mitochondrial proteins; risk; randomization study; mendelian randomization ... See more keywords
Genetically rheumatoid arthrits and risk of comorbidities: a Mendelian randomization study
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DOI: 10.1093/ehjci/ehaa946.3152
Abstract: Ample observational evidence indicates that patients with rheumatoid arthritis (RA) are at increased risk of developing comorbid conditions, in particular cardiovascular disease. The pathogenesis of these comorbidities is still largely unknown. For effective preventive measures,… read more here.
Keywords: randomization study; risk; randomization; mendelian randomization ... See more keywords
Central obesity as a potential causal risk factor for atrial fibrillation: evidence from Mendelian randomization study
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DOI: 10.1093/europace/euae061
Abstract: Graphical Abstract Graphical Abstract (A) Overview and assumptions of the Mendelian randomization study. Assumption 1: the genetic variants should be strongly associated with the risk factor; Assumption 2: the genetic variants should not be associated… read more here.
Keywords: randomization study; risk factor; risk; mendelian randomization ... See more keywords
A Mendelian randomization study finds no evidence for causal effects of C-reactive protein (CRP) on chronic pain conditions.
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DOI: 10.1093/pm/pnae122
Abstract: This two-sample Mendelian randomization study examined causal associations of C-reactive protein (CRP) with spinal pain, the extent of multisite chronic pain, and chronic widespread musculoskeletal pain. No causal associations were found between CRP and these… read more here.
Keywords: pain; chronic pain; randomization study; protein crp ... See more keywords
The causal relationship of serum uric acid on colorectal cancer: A Mendelian randomization study
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DOI: 10.1097/md.0000000000038722
Abstract: Colorectal cancer (CRC) is a significant public health issue owing to its widespread occurrence and substantial morbidity and mortality rates. Recent studies have highlighted serum uric acid (SUA) level as a probable risk factor for… read more here.
Keywords: colorectal cancer; serum uric; randomization study; mendelian randomization ... See more keywords