A phase 1 and randomized, placebo‐controlled phase 2 trial of bevacizumab plus dasatinib in patients with recurrent glioblastoma: Alliance/North Central Cancer Treatment Group N0872
Sign Up to like & getrecommendations! Published in 2019 at "Cancer"
DOI: 10.1002/cncr.32340
Abstract: Src signaling is markedly upregulated in patients with invasive glioblastoma (GBM) after the administration of bevacizumab. The Src family kinase inhibitor dasatinib has been found to effectively block bevacizumab‐induced glioma invasion in preclinical models, which… read more here.
Keywords: bevacizumab; placebo controlled; randomized placebo; phase randomized ... See more keywords
Safety, Pharmacokinetics, and Pharmacodynamics of Etavopivat (FT-4202), an Allosteric Activator of Pyruvate Kinase-R, in Healthy Adults: A Randomized, Placebo-Controlled, Double-Blind, First-in-Human Phase 1 Trial.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical pharmacology in drug development"
DOI: 10.1002/cpdd.1058
Abstract: Etavopivat (FT-4202) is an orally administered, small-molecule allosteric activator of erythrocyte pyruvate kinase-R (PKR) in clinical development for the treatment of sickle cell disease and other hemoglobin disorders. This randomized, placebo-controlled, double-blind, first-in-human combination single-ascending… read more here.
Keywords: safety; placebo; randomized placebo; allosteric activator ... See more keywords
Biperiden Challenge Model in Healthy Elderly as Proof‐of‐Pharmacology Tool: A Randomized, Placebo‐Controlled Trial
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Pharmacology"
DOI: 10.1002/jcph.1913
Abstract: Selective M1 muscarinic acetylcholine receptor (mAChR) agonists are being developed as symptomatic treatment for neurodegenerative and neuropsychiatric disorders that lead to cognitive dysfunction. Demonstrating cognition‐enhancing effects in early‐phase clinical development in healthy subjects is difficult.… read more here.
Keywords: healthy elderly; biperiden; randomized placebo; pharmacology ... See more keywords
18: Randomized placebo‐controlled trial of onabotulinamtoxina trigger point injections for myofascial pelvic pain
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Obstetrics and Gynecology"
DOI: 10.1016/j.ajog.2019.01.028
Abstract: assessed from a visit between 3 months and 2 years after surgery. The primary outcome was anatomic failure, defined as recurrent prolapse beyond the hymen or retreatment for prolapse with surgery or pessary. We performed… read more here.
Keywords: posterior repair; anatomic failure; placebo controlled; randomized placebo ... See more keywords
Effects of Auriculotherapy on treatment of women with premenstrual syndrome symptoms: A randomized, placebo-controlled clinical trial.
Sign Up to like & getrecommendations! Published in 2022 at "Complementary therapies in medicine"
DOI: 10.1016/j.ctim.2022.102816
Abstract: OBJECTIVE This study aimed to investigate the effect of auriculotherapy on the intensity of physical and mood Premenstrual syndrome (PMS) symptoms. DESIGN Single-blind randomized, placebo-controlled clinical trial. SETTING Federal University of Parana, Curitiba, Brazil. INTERVENTION… read more here.
Keywords: randomized placebo; placebo controlled; pms symptoms; controlled clinical ... See more keywords
Evolving role of regorafenib for the treatment of advanced cancers.
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DOI: 10.1016/j.ctrv.2020.101993
Abstract: Regorafenib is an oral tyrosine kinase inhibitor (TKI) approved for the treatment of refractory metastatic colorectal cancer (mCRC), advanced gastrointestinal stromal tumors (GIST) previously treated with imatinib and sunitinib, and unresectable hepatocellular carcinoma (HCC) following… read more here.
Keywords: placebo controlled; treatment; controlled phase; randomized placebo ... See more keywords
A double-blind randomized placebo-controlled trial of probiotics in systemic sclerosis associated gastrointestinal disease.
Sign Up to like & getrecommendations! Published in 2019 at "Seminars in arthritis and rheumatism"
DOI: 10.1016/j.semarthrit.2019.05.006
Abstract: OBJECTIVE Assess whether treatment with probiotics improve gastrointestinal symptoms in patients with systemic sclerosis (SSc). METHODS In this double-blind randomized placebo-controlled parallel-group phase II trial, SSc subjects with total score ≥ 0.1 on a validated SSc-specific… read more here.
Keywords: placebo; double blind; randomized placebo; systemic sclerosis ... See more keywords
Effect of eicosapentaenoic acid and docosahexaenoic acid supplementation on C-peptide preservation in pregnant women with type-1 diabetes: randomized placebo controlled clinical trial
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Clinical Nutrition"
DOI: 10.1038/ejcn.2017.46
Abstract: Background/Objectives:Type-1 diabetes mellitus (T1DM) is caused by autoimmune insulitis. There are evidences that pregnancy and n-3 fatty acids exhibit suppressive effect on human inflammatory system.Subjects/Methods:Ninety pregnant women with T1DM were included in the prospective randomized… read more here.
Keywords: pregnant women; third trimester; randomized placebo; type diabetes ... See more keywords
Is there value in using randomized placebo controlled trials in neuromuscular disease?
Sign Up to like & getrecommendations! Published in 2020 at "Expert Review of Neurotherapeutics"
DOI: 10.1080/14737175.2020.1834854
Abstract: References to placebos and the placebo effect have come down to us from ancient Egypt. The placebo effect on outcomes is considerable and increasing, even in neuromuscular disease (NMD) studies. A ... read more here.
Keywords: value using; using randomized; neuromuscular disease; randomized placebo ... See more keywords
Effect of Theaflavin on Oral Bacteria in Japanese Subjects: A Randomized, Placebo-Controlled, Double-Blind Study.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal food"
DOI: 10.1089/jmf.2021.k.0050
Abstract: Black tea is a popular beverage worldwide. Theaflavins (TFs), which are active functional components of black tea, are potentially valuable for preventing and/or treating the progression of periodontal diseases. Our previous pilot study showed that… read more here.
Keywords: placebo; oral bacteria; study; placebo controlled ... See more keywords
Effects of varenicline and bupropion on laboratory smoking outcomes: Meta‐analysis of randomized, placebo‐controlled human laboratory studies
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DOI: 10.1111/adb.13218
Abstract: Human laboratory studies are widely used to evaluate behavioural mechanisms of pharmacotherapy effects. Results from human laboratory studies examining smoking cessation pharmacotherapies have not been examined in aggregate. The current meta‐analysis aimed to synthesize data… read more here.
Keywords: laboratory; meta analysis; randomized placebo; human laboratory ... See more keywords