Long‐term overall survival and toxicities of ABVD vs BEACOPP in advanced Hodgkin lymphoma: A pooled analysis of four randomized trials
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Medicine"
DOI: 10.1002/cam4.3298
Abstract: We explored the potential overall survival (OS) benefit of bleomycin, etoposide, doxorubicin (Adriamycin), cyclophosphamide, vincristine (Oncovin), procarbazine, and prednisone (BEACOPP) over doxorubicin (Adriamycin), bleomycin, vinblastine, and dacarbazine (ABVD) in a pooled analysis of four randomized… read more here.
Keywords: analysis four; four randomized; overall survival; pooled analysis ... See more keywords
Associations between safety, tolerability, and toxicity and the reporting of health‐related quality of life in phase III randomized trials in common solid tumors
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DOI: 10.1002/cam4.3390
Abstract: Anti‐cancer drugs are approved typically on the basis of efficacy and safety as evaluated in phase III randomized trials (RCTs). Health‐related quality of life (HRQoL) is a direct measure of patient benefit, but is under‐reported.… read more here.
Keywords: phase; health related; iii randomized; phase iii ... See more keywords
Patient, Physician, and Assessor Blinding in Phase III Randomized Trials in Oncology: A Meta‐Epidemiological Analysis
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DOI: 10.1002/cam4.71097
Abstract: Blinding mitigates bias in randomized trials and may be especially crucial for surrogate endpoints, such as progression‐free survival (PFS). Here, we characterize utilization of and factors associated with blinding in Phase III oncology trials with… read more here.
Keywords: oncology; phase iii; blinding phase; randomized trials ... See more keywords
Describing the nonsurgical, nonpharmacological interventions offered to adolescents with persistent back pain in randomized trials: A scoping review
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Pain"
DOI: 10.1002/ejp.2073
Abstract: Persistent nonspecific back pain is now established as a biopsychosocial phenomenon that can be meaningfully affected by individuals' cognitions, emotions, lifestyle factors and family and social relationships. Recent guidelines for the treatment of adolescents with… read more here.
Keywords: adolescents persistent; scoping review; randomized trials; persistent back ... See more keywords
Bayesian network meta-analysis for cluster randomized trials with binary outcomes.
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DOI: 10.1002/jrsm.1210
Abstract: Network meta-analysis is becoming a common approach to combine direct and indirect comparisons of several treatment arms. In recent research, there have been various developments and extensions of the standard methodology. Simultaneously, cluster randomized trials… read more here.
Keywords: network meta; randomized trials; cluster randomized; meta analysis ... See more keywords
Construct validity of the Physiotherapy Evidence Database (PEDro) quality scale for randomized trials: Item response theory and factor analyses
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DOI: 10.1002/jrsm.1385
Abstract: Background There is an agreement that the methodological quality of randomized trials should be assessed in systematic reviews, but there is a debate on how this should be done. We conducted a construct validation study… read more here.
Keywords: quality; construct; evidence; randomized trials ... See more keywords
Model‐Robust Standardization in Cluster‐Randomized Trials
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DOI: 10.1002/sim.70270
Abstract: In cluster‐randomized trials, generalized linear mixed models and generalized estimating equations have conventionally been the default analytic methods for estimating the average treatment effect as routine practice. However, recent studies have demonstrated that their treatment… read more here.
Keywords: cluster randomized; treatment; cluster; model robust ... See more keywords
What are the statistical implications of treatment non‐compliance in cluster randomized trials: A simulation study
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DOI: 10.1002/sim.8351
Abstract: Subjects in randomized controlled trials do not always comply to the treatment condition they have been assigned to. This may cause the estimated effect of the intervention to be biased and also affect efficiency, coverage… read more here.
Keywords: non compliance; compliance; cluster randomized; level ... See more keywords
Novel methods for the analysis of stepped wedge cluster randomized trials.
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DOI: 10.1002/sim.8451
Abstract: Stepped wedge cluster randomized trials (SW-CRTs) have become increasingly popular and are used for a variety of interventions and outcomes, often chosen for their feasibility advantages. SW-CRTs must account for time trends in the outcome… read more here.
Keywords: analysis; cluster randomized; stepped wedge; wedge cluster ... See more keywords
Sample size calculation for randomized trials via inverse probability of response weighting when outcome data are missing at random
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DOI: 10.1002/sim.9700
Abstract: Randomized trials are an established method to evaluate the causal effects of interventions. Despite concerted efforts to retain all trial participants, some missing outcome data are often inevitable. It is unclear how best to account… read more here.
Keywords: outcome data; size; sample size; randomized trials ... See more keywords
Impact of CPAP on arterial stiffness in patients with obstructive sleep apnea: a meta-analysis of randomized trials
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DOI: 10.1007/s11325-020-02226-7
Abstract: This study aimed to perform a systematic review and meta-analysis of randomized trials investigating the effect of continuous positive airway pressure (CPAP) on non-invasive markers of arterial stiffness in patients with OSA. The purpose of… read more here.
Keywords: analysis; randomized trials; arterial stiffness; meta analysis ... See more keywords