Long‐term overall survival and toxicities of ABVD vs BEACOPP in advanced Hodgkin lymphoma: A pooled analysis of four randomized trials
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Medicine"
DOI: 10.1002/cam4.3298
Abstract: We explored the potential overall survival (OS) benefit of bleomycin, etoposide, doxorubicin (Adriamycin), cyclophosphamide, vincristine (Oncovin), procarbazine, and prednisone (BEACOPP) over doxorubicin (Adriamycin), bleomycin, vinblastine, and dacarbazine (ABVD) in a pooled analysis of four randomized… read more here.
Keywords: analysis four; four randomized; overall survival; pooled analysis ... See more keywords
Associations between safety, tolerability, and toxicity and the reporting of health‐related quality of life in phase III randomized trials in common solid tumors
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Medicine"
DOI: 10.1002/cam4.3390
Abstract: Anti‐cancer drugs are approved typically on the basis of efficacy and safety as evaluated in phase III randomized trials (RCTs). Health‐related quality of life (HRQoL) is a direct measure of patient benefit, but is under‐reported.… read more here.
Keywords: phase; health related; iii randomized; phase iii ... See more keywords
Describing the nonsurgical, nonpharmacological interventions offered to adolescents with persistent back pain in randomized trials: A scoping review
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Pain"
DOI: 10.1002/ejp.2073
Abstract: Persistent nonspecific back pain is now established as a biopsychosocial phenomenon that can be meaningfully affected by individuals' cognitions, emotions, lifestyle factors and family and social relationships. Recent guidelines for the treatment of adolescents with… read more here.
Keywords: adolescents persistent; scoping review; randomized trials; persistent back ... See more keywords
Bayesian network meta-analysis for cluster randomized trials with binary outcomes.
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DOI: 10.1002/jrsm.1210
Abstract: Network meta-analysis is becoming a common approach to combine direct and indirect comparisons of several treatment arms. In recent research, there have been various developments and extensions of the standard methodology. Simultaneously, cluster randomized trials… read more here.
Keywords: network meta; randomized trials; cluster randomized; meta analysis ... See more keywords
Construct validity of the Physiotherapy Evidence Database (PEDro) quality scale for randomized trials: Item response theory and factor analyses
Sign Up to like & getrecommendations! Published in 2019 at "Research Synthesis Methods"
DOI: 10.1002/jrsm.1385
Abstract: Background There is an agreement that the methodological quality of randomized trials should be assessed in systematic reviews, but there is a debate on how this should be done. We conducted a construct validation study… read more here.
Keywords: quality; construct; evidence; randomized trials ... See more keywords
What are the statistical implications of treatment non‐compliance in cluster randomized trials: A simulation study
Sign Up to like & getrecommendations! Published in 2019 at "Statistics in Medicine"
DOI: 10.1002/sim.8351
Abstract: Subjects in randomized controlled trials do not always comply to the treatment condition they have been assigned to. This may cause the estimated effect of the intervention to be biased and also affect efficiency, coverage… read more here.
Keywords: non compliance; compliance; cluster randomized; level ... See more keywords
Novel methods for the analysis of stepped wedge cluster randomized trials.
Sign Up to like & getrecommendations! Published in 2019 at "Statistics in medicine"
DOI: 10.1002/sim.8451
Abstract: Stepped wedge cluster randomized trials (SW-CRTs) have become increasingly popular and are used for a variety of interventions and outcomes, often chosen for their feasibility advantages. SW-CRTs must account for time trends in the outcome… read more here.
Keywords: analysis; cluster randomized; stepped wedge; wedge cluster ... See more keywords
Sample size calculation for randomized trials via inverse probability of response weighting when outcome data are missing at random
Sign Up to like & getrecommendations! Published in 2023 at "Statistics in Medicine"
DOI: 10.1002/sim.9700
Abstract: Randomized trials are an established method to evaluate the causal effects of interventions. Despite concerted efforts to retain all trial participants, some missing outcome data are often inevitable. It is unclear how best to account… read more here.
Keywords: outcome data; size; sample size; randomized trials ... See more keywords
Impact of CPAP on arterial stiffness in patients with obstructive sleep apnea: a meta-analysis of randomized trials
Sign Up to like & getrecommendations! Published in 2020 at "Sleep and Breathing"
DOI: 10.1007/s11325-020-02226-7
Abstract: This study aimed to perform a systematic review and meta-analysis of randomized trials investigating the effect of continuous positive airway pressure (CPAP) on non-invasive markers of arterial stiffness in patients with OSA. The purpose of… read more here.
Keywords: analysis; randomized trials; arterial stiffness; meta analysis ... See more keywords
Benchmarking Observational Analyses Against Randomized Trials: a Review of Studies Assessing Propensity Score Methods
Sign Up to like & getrecommendations! Published in 2020 at "Journal of General Internal Medicine"
DOI: 10.1007/s11606-020-05713-5
Abstract: Background Observational analysis methods can be refined by benchmarking against randomized trials. We reviewed studies systematically comparing observational analyses using propensity score methods against randomized trials to explore whether intervention or outcome characteristics predict agreement… read more here.
Keywords: observational analyses; propensity score; propensity; randomized trials ... See more keywords
The Restricted Mean Survival Time as a Tool for Ranking Comparative Outcomes in a Narrative Review that Evaluates a Network of Randomized Trials: An Example Based on PCSK9 Inhibitors
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Cardiovascular Drugs"
DOI: 10.1007/s40256-020-00444-8
Abstract: Introduction On the basis of two randomized trials, evolocumab and alirocumab have been approved in patients with cardiovascular disease. The evidence on these two agents has been studied through different methods of analysis that span… read more here.
Keywords: survival time; network; narrative review; restricted mean ... See more keywords