Chasing long‐range evolutionary couplings in the AlphaFold era
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DOI: 10.1002/bip.23530
Abstract: Coevolution between protein residues is normally interpreted as direct contact. However, the evolutionary record of a protein sequence contains rich information that may include long‐range functional couplings, couplings that report on homo‐oligomeric states or even… read more here.
Keywords: alphafold era; chasing long; long range; range evolutionary ... See more keywords
Nature of Long-Range Evolutionary Constraint in Enzymes: Insights from Comparison to Pseudoenzymes with Similar Structures
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DOI: 10.1093/molbev/msy177
Abstract: Enzymes are known to fine-tune their sequences to optimize catalytic function, yet quantitative evolutionary design principles of enzymes remain elusive on the proteomic scale. Recently, it was found that the catalytic site in enzymes induces… read more here.
Keywords: constraint enzymes; evolutionary constraint; long range; range evolutionary ... See more keywords