Prolactin regulates RANKL expression via signal transducer and activator of transcription 5a signaling in mammary epithelial cells of dairy cows
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DOI: 10.1002/cbin.11988
Abstract: Receptor of activated nuclear factor kappa B ligand (RANKL) is regulated by prolactin in the mammary gland. However, the intrinsic molecular mechanism is not well understood. Herein, mammary epithelial cells (MECs) of dairy cows were… read more here.
Keywords: expression; rankl; epithelial cells; prolactin ... See more keywords
LRP1 Suppresses Bone Resorption in Mice by Inhibiting the RANKL‐Stimulated NF‐κB and p38 Pathways During Osteoclastogenesis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.3469
Abstract: Single‐nucleotide polymorphisms in the LRP1 gene coding sequence are associated with low bone mass, and cell culture studies suggest that LRP1 plays a role in osteoblast proliferation and osteoblast‐mediated osteoclastogenesis. However, the in vivo function… read more here.
Keywords: p38 pathways; lrp1; bone; mice ... See more keywords
Osteoblasts/Osteocytes sirtuin6 Is Vital to Preventing Ischemic Osteonecrosis Through Targeting VDR‐RANKL Signaling
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4207
Abstract: Ischemic osteonecrosis (ION) can produce permanent deformity and osteoarthritis in the femoral head and other joints. No biologic treatment has been established, and the molecular mechanisms involved in the pathogenesis of ION have not been… read more here.
Keywords: osteoblasts osteocytes; bone; ischemic osteonecrosis; sirt6 ... See more keywords
RANKL Blockade Reduces Cachexia and Bone Loss Induced by Non‐Metastatic Ovarian Cancer in Mice
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4480
Abstract: Tumor‐ and bone‐derived soluble factors have been proposed to participate in the alterations of skeletal muscle size and function in cachexia. We previously showed that mice bearing ovarian cancer (OvCa) exhibit cachexia associated with marked… read more here.
Keywords: bone; rankl; muscle; cachexia ... See more keywords
Characterization of Extracellular Vesicles in Osteoporotic Patients Compared to Osteopenic and Healthy Controls
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4688
Abstract: Extracellular vesicles (EVs) are mediators of a range of pathological conditions. However, their role in bone loss disease has not been well understood. In this study we characterized plasma EVs of 54 osteoporotic (OP) postmenopausal… read more here.
Keywords: extracellular vesicles; bone; healthy controls; rankl ... See more keywords
Picroside II Inhibits RANKL‐Mediated Osteoclastogenesis by Attenuating the NF‐κB and MAPKs Signaling Pathway In Vitro and Prevents Bone Loss in Lipopolysaccharide Treatment Mice
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26105
Abstract: Picroside II, one of the major components isolated from the seed of natural plant picrorhiza, is widely used in traditional Chinese medicine. The present study was performed to define effects of picroside II on nuclear… read more here.
Keywords: treatment; rankl; bone loss; lipopolysaccharide ... See more keywords
Achyranthes bidentata polysaccharide suppresses osteoclastogenesis and bone resorption via inhibiting RANKL signaling
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26682
Abstract: Osteoclasts are highly differentiated multinucleated giant cells that play fundamental roles in bone resorption and in the pathogenesis of osteolytic conditions, such as osteoporosis and cancer‐induced bone loss. Achyranthes bidentata polysaccharide (ABP) is a hydrophilic… read more here.
Keywords: bidentata polysaccharide; achyranthes bidentata; bone resorption; resorption ... See more keywords
Daphnetin attenuates LPS‐induced osteolysis and RANKL mediated osteoclastogenesis through suppression of ERK and NFATc1 pathways
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28408
Abstract: Aseptic prosthetic loosening and periprosthetic infection resulting in inflammatory osteolysis is a leading complication of total joint arthroplasty (TJA). Excessive bone destruction around the bone and prosthesis interface plays a key role in the loosening… read more here.
Keywords: daphnetin; bone; erk nfatc1; osteolysis ... See more keywords
HIF‐1α facilitates osteocyte‐mediated osteoclastogenesis by activating JAK2/STAT3 pathway in vitro
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28721
Abstract: Osteocytes, entrapped within the mineralized bone matrix, has been found to have numerous functions such as acting as an orchestrator of bone remodeling through regulation of both osteoclast and osteoblast activity and also functioning as… read more here.
Keywords: hif; jak2 stat3; rankl; stat3 pathway ... See more keywords
Association of RANK and RANKL gene polymorphism with survival and calcium levels in multiple myeloma
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DOI: 10.1002/mc.23272
Abstract: Multiple myeloma (MM) is a heterogeneous bone marrow cancer characterized by proliferation of malignant plasma cells in the bone marrow. One of its major symptoms are hypercalcaemia and bone lesions, which may result in pathologic… read more here.
Keywords: multiple myeloma; bone; calcium; rankl ... See more keywords
The Role of TAK1 in RANKL-Induced Osteoclastogenesis.
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DOI: 10.1007/s00223-022-00967-z
Abstract: Bone remodelling is generally a dynamic process orchestrated by bone-resorbing osteoclasts and bone-forming osteoblasts. Osteoclasts are the only cell type capable of bone resorption to maintain bone homeostasis in the human body. However, excessive osteoclastogenesis… read more here.
Keywords: rankl; role tak1; induced osteoclastogenesis; rankl induced ... See more keywords