Coenzyme Q10 inhibits RANKL‐induced osteoclastogenesis by regulation of mitochondrial apoptosis and oxidative stress in RAW264.7 cells
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22778
Abstract: Coenzyme Q10 (CoQ10) has been reported to improve bone density and the number of trabeculae in postmenopausal osteoporosis, but the mechanism remains to be elucidated. We aimed to investigate the effects of CoQ10 on receptor… read more here.
Keywords: induced osteoclastogenesis; rankl induced; mitochondrial apoptosis; raw264 cells ... See more keywords
Cyanidin Chloride inhibits ovariectomy‐induced osteoporosis by suppressing RANKL‐mediated osteoclastogenesis and associated signaling pathways
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26126
Abstract: Over‐production and activation of osteoclasts is a common feature of osteolytic conditions such as osteoporosis, tumor‐associated osteolysis, and inflammatory bone erosion. Cyanidin Chloride, a subclass of anthocyanin, displays antioxidant and anti‐carcinogenesis properties, but its role… read more here.
Keywords: chloride inhibits; rankl induced; ovariectomy induced; chloride ... See more keywords
Abietic acid attenuates RANKL induced osteoclastogenesis and inflammation associated osteolysis by inhibiting the NF‐KB and MAPK signaling
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26575
Abstract: Osteoporosis is a major debilitating cause of fractures and decreases the quality of life in elderly patients. Bone homeostasis is maintained by bone forming osteoblasts and bone resorpting osteoclasts. Substantial evidences have shown that targeting… read more here.
Keywords: induced osteoclastogenesis; rankl induced; mapk signaling; osteolysis ... See more keywords
Hesperetin suppresses RANKL‐induced osteoclastogenesis and ameliorates lipopolysaccharide‐induced bone loss
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27924
Abstract: Destructive bone diseases caused by osteolysis are increasing in incidence. They are characterized by an excessive imbalance of osteoclast formation and activation. During osteolysis, the activation of nuclear factor‐κB (NF‐κB) and mitogen‐activated protein kinase (MAPK)… read more here.
Keywords: induced osteoclastogenesis; induced bone; rankl induced; bone ... See more keywords
Chitooligosaccharide inhibits RANKL‐induced osteoclastogenesis and ligation‐induced periodontitis by suppressing MAPK/ c‐fos/NFATC1 signaling
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29207
Abstract: Considering the high rate of osteoclast‐related diseases worldwide, research targeting osteoclast formation/function is crucial. In vitro, we demonstrated that chitooligosaccharide (CS) dramatically inhibited osteoclastogenesis as well as osteoclast function dose‐dependently. CS suppressed osteoclast‐specific genes expression… read more here.
Keywords: induced osteoclastogenesis; mapk fos; fos nfatc1; rankl induced ... See more keywords
Inhibitory effect of sulphated polysaccharide porphyran (isolated from Porphyra yezoensis) on RANKL‐induced differentiation of RAW264.7 cells into osteoclasts
Sign Up to like & getrecommendations! Published in 2018 at "Phytotherapy Research"
DOI: 10.1002/ptr.5988
Abstract: Safe and efficient therapeutic agents for bone diseases are required in natural sources. We previously found that edible seaweed‐derived polysaccharide porphyran exhibited anti‐inflammatory effects through the down regulation of nuclear factor‐κB. The aim of this… read more here.
Keywords: rankl induced; porphyran; raw264 cells; polysaccharide porphyran ... See more keywords
The Role of TAK1 in RANKL-Induced Osteoclastogenesis.
Sign Up to like & getrecommendations! Published in 2022 at "Calcified tissue international"
DOI: 10.1007/s00223-022-00967-z
Abstract: Bone remodelling is generally a dynamic process orchestrated by bone-resorbing osteoclasts and bone-forming osteoblasts. Osteoclasts are the only cell type capable of bone resorption to maintain bone homeostasis in the human body. However, excessive osteoclastogenesis… read more here.
Keywords: rankl; role tak1; induced osteoclastogenesis; rankl induced ... See more keywords
Sclareol inhibits RANKL-induced osteoclastogenesis and promotes osteoblastogenesis through promoting CCN1 expression via repressing the MAPK pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Cell biology and toxicology"
DOI: 10.1007/s10565-020-09578-6
Abstract: Osteoclasts are crucial cellular components of bone and are the cause of various bone problems like osteoporosis. Various biological activities such as anti-tumorous, anti-inflammatory, antibacterial, and immunomodulatory function are influenced by Sclareol, as a natural… read more here.
Keywords: sclareol; mapk pathway; rankl induced; bone ... See more keywords
Gingipains promote RANKL-induced osteoclastogenesis through the enhancement of integrin β3 in RAW264.7 cells
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Histology"
DOI: 10.1007/s10735-020-09865-w
Abstract: As a crucial virulence factor of Porphyromonas gingivalis , gingipains play an important role in periodontal destruction. This study aimed to investigate the effect of gingipains on osteoclastogenesis. We used RAW264.7 cells as osteoclast precursors… read more here.
Keywords: osteoclastogenesis; integrin; rankl induced; factor ... See more keywords
Cyclolinopeptide F, a cyclic peptide from flaxseed inhibited RANKL-induced osteoclastogenesis via downergulation of RANK expression
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Natural Medicines"
DOI: 10.1007/s11418-019-01292-w
Abstract: Previously, we reported that cyclolinopeptides (CLs) extracted from flaxseed inhibited receptor activator of nuclear factor κ-B ligand (RANKL)-induced osteoclastogenesis from mouse bone marrow cells in vitro. However, mode of action involved in CLs-inhibited osteoclastogenesis has… read more here.
Keywords: induced osteoclastogenesis; rankl induced; expression; osteoclastogenesis ... See more keywords
Discovery of diverse diterpenoid scaffolds from Euphorbia antiquorum and their activity against RANKL-induced osteoclastogenesis.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.103292
Abstract: Seven new diterpenoids, euphorantones A-D (1, 3, 6, and 10), 8,12,13-epi-3,7,12-O-triacetyl-8-O-(2-methylbutanoyl)-ingol (9), 8,12,13-epi-3,12-O-diacetyl-7-O-benzoyl-8-methoxyingol (11), 2,3-epi-7,12-diacetate-8-benzoate-ingol (12), together with eighteen known compounds (2, 4-5, 7-8, and 13-25), were isolated from the aerial parts of Euphorbia antiquorum… read more here.
Keywords: discovery diverse; induced osteoclastogenesis; euphorbia antiquorum; rankl induced ... See more keywords