Discovery of the RANKL/RANK/OPG system
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Bone and Mineral Metabolism"
DOI: 10.1007/s00774-020-01175-1
Abstract: Almost a quarter century has passed since discovery of receptor activator of NF-κB ligand (RANKL). This discovery had a major impact on identification of mechanisms regulating osteoclast differentiation and function, establishment of a research field… read more here.
Keywords: rankl rank; opg; system; discovery ... See more keywords
Cynomorium songaricum prevents bone resorption in ovariectomized rats through RANKL/RANK/TRAF6 mediated suppression of PI3K/AKT and NF‐&kgr;B pathways
Sign Up to like & getrecommendations! Published in 2018 at "Life Sciences"
DOI: 10.1016/j.lfs.2018.08.008
Abstract: Aim: Cynomorium songaricum Rupr., an edible and important Traditional Chinese medicine has long been used in folk for treatment of kidney deficiency, was chosen to estimate the antiosteoporotic activity and underlying molecular mechanism on rats… read more here.
Keywords: rankl rank; pi3k; ovariectomized rats; bone resorption ... See more keywords
RANKL and RANK: From Mammalian Physiology to Cancer Treatment.
Sign Up to like & getrecommendations! Published in 2018 at "Trends in cell biology"
DOI: 10.1016/j.tcb.2017.11.001
Abstract: The tumor necrosis factor (TNF) receptor RANK (TNFRSF11A) and its ligand RANKL (TNFSF11) regulate osteoclast development and bone metabolism. They also control stem cell expansion and proliferation of mammary epithelial cells via the sex hormone… read more here.
Keywords: cancer; rankl rank; physiology; breast cancer ... See more keywords
P0690CORRELATIONS BETWEEN OPG/RANKL/RANK AXIS, VITAMIN D STATUS, PTH AND VASCULAR CALCIFICATION IN AN ADENINE-INDUCED MODEL OF CHRONIC KIDNEY DISEASE
Sign Up to like & getrecommendations! Published in 2020 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfaa142.p0690
Abstract: Chronic kidney disease (CKD) is a major public health problem worldwide and refers to a wide range of disorders in bone and mineral metabolism, abnormalities of biochemical parameters and pathological calcification of the blood vessels.… read more here.
Keywords: opg rankl; rankl rank; gene; gene expression ... See more keywords
Soy Isoflavones and Bone Health: Focus on the RANKL/RANK/OPG Pathway
Sign Up to like & getrecommendations! Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/8862278
Abstract: Bone remodels via resorption and formation, two phenomena that continuously occur in bone turnover. The RANKL/RANK/OPG pathway is one of the several mechanisms that affect bone turnover. The RANKL/OPG ratio has a substantial role in… read more here.
Keywords: opg pathway; bone; rank opg; rankl ... See more keywords
The regulatory role of the RANKL/RANK/OPG signaling pathway in the mechanisms of tooth eruption in patients with impacted teeth
Sign Up to like & getrecommendations! Published in 2020 at "BMC Oral Health"
DOI: 10.1186/s12903-020-01251-y
Abstract: Background Tooth impaction is a common problem in orthodontic practice and in some cases accompanied by pain and pathological changes of surrounding teeth. Understanding the cellular and molecular mechanisms underlying tooth impaction allows finding the… read more here.
Keywords: rankl rank; rank opg; tooth eruption; rank ... See more keywords
Combining denosumab (D) and trastuzumab (T) as a novel treatment strategy in HER2-positive (+) breast carcinomas (BC).
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.e12506
Abstract: e12506 Background: HER-2 is overexpressed in 20–30% of BC, indicating poor prognosis. RANKL/RANK pathway is implicated in HER-2(+) BC. The molecular mechanism and the potential of dual targeting have been evaluated and showed promising results.… read more here.
Keywords: treatment; rank; rankl rank; skbr3 bt474 ... See more keywords
Roles of the RANKL–RANK Axis in Immunity—Implications for Pathogenesis and Treatment of Bone Metastasis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.824117
Abstract: A substantial amount patients with cancer will develop bone metastases, with 70% of metastatic prostate and breast cancer patients harboring bone metastasis. Despite advancements in systemic therapies for advanced cancer, survival remains poor for those… read more here.
Keywords: bone; bone metastasis; bone metastases; cancer ... See more keywords
RANKL-RANK-OPG Pathway in Charcot Diabetic Foot: Pathophysiology and Clinical-Therapeutic Implications
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24033014
Abstract: Charcot Foot (CF), part of a broader condition known as Charcot Neuro-Osteoarthropathy (CNO), is characterized by neuropathic arthropathy with a progressive alteration of the foot. CNO is one of the most devastating complications in patients… read more here.
Keywords: therapeutic implications; rankl rank; opg pathway; foot ... See more keywords
Association of Genes Variants in RANKL/RANK/OPG Signaling Pathway with the Development of Osteonecrosis of the Femoral Head in Chinese Population
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Medical Sciences"
DOI: 10.7150/ijms.19124
Abstract: The RANKL/RANK/OPG pathway plays an important role in regulating bone remodeling and bone turnover. However, the association of the genes variants with the risk of ONFH has rarely been reported. Here, we analyzed the correlation… read more here.
Keywords: rankl rank; rank opg; association genes; chinese population ... See more keywords