Digitalis Promotes Ventricular Arrhythmias in Flecainide- and Ranolazine-Pretreated Hearts
Sign Up to like & getrecommendations! Published in 2018 at "Cardiovascular Toxicology"
DOI: 10.1007/s12012-018-9494-7
Abstract: A post hoc analysis of the PALLAS trial suggested life-threatening interactions of digitalis and dronedarone. Thus, there is concern about an interplay between digitalis and other drugs that influence cardiac electrophysiology. We therefore investigated the… read more here.
Keywords: iqr; ranolazine; iqr erp; digitalis promotes ... See more keywords
Response to letter regarding article, "Effects of the antianginal drugs ranolazine, nicorandil and ivabradine on coronary microvascular function in patients with non-obstructive coronary artery disease: a meta-analysis of randomized controlled trials".
Sign Up to like & getrecommendations! Published in 2020 at "Clinical therapeutics"
DOI: 10.1016/j.clinthera.2019.12.016
Abstract: We thank Dr. Tolunay for expanding our point regarding the effect of ranolazine on chest pain in patients with coronary microcirculation dysfunction from our recent meta-analysis (Effects of the Antianginal Drugs Ranolazine, Nicorandil, and Ivabradine… read more here.
Keywords: antianginal drugs; ranolazine; effects antianginal; meta analysis ... See more keywords
Comparison of Pharmacokinetics and Safety of Ranolazine PR between Koreans and Caucasians.
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DOI: 10.1016/j.clinthera.2021.01.005
Abstract: PURPOSE Ranolazine, an inhibitor of late inward sodium current, is an antianginal agent. In this study, the pharmacokinetic (PK) properties and tolerability of single- and multiple-dose ranolazine were compared between healthy Koreans and Caucasians. METHODS… read more here.
Keywords: ranolazine; difference; koreans caucasians; safety ... See more keywords
Ranolazine for rhythm control in atrial fibrillation: A systematic review and meta-analysis.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2016.11.103
Abstract: BACKGROUND/OBJECTIVES Available pharmacological options for rhythm control strategy in atrial fibrillation (AF) are limited by sub-optimal efficacy and potentially serious adverse events. The aim of the present meta-analysis is to determine the efficacy and safety… read more here.
Keywords: rhythm control; control; ranolazine; meta analysis ... See more keywords
Ranolazine in patients with type 2 diabetes and chronic angina: A cost-effectiveness analysis and assessment of health-related quality-of-life.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2018.09.060
Abstract: BACKGROUND Type 2 diabetes (T2D) is associated with a high burden of angina. Ranolazine has been shown to reduce angina frequency versus placebo in patients with T2D and stable angina. We sought to estimate the… read more here.
Keywords: ranolazine; angina; cost; type diabetes ... See more keywords
Development of ethosomal gel of ranolazine for improved topical delivery: In vitro and ex vivo evaluation
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DOI: 10.1016/j.molliq.2016.11.114
Abstract: Abstract Ranolazine loaded ethosomal system were developed by varying the proportion of soya lecithin (0.9–1.5% w/v) and ethanol (20–40% w/v). The prepared ethosomal formulations (RET1-RET9) were evaluated in vitro for vesicle shape and size, zeta… read more here.
Keywords: ranolazine; vivo; ethosomal gel; delivery ... See more keywords
Ranolazine-induced lipid storage myopathy presenting with respiratory failure and head drop
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DOI: 10.1016/j.nmd.2021.03.004
Abstract: Ranolazine is an anti-ischemic drug often used along with statins in patients with ischemic heart disease. Ranolazine-induced proximal myopathy or rhabdomyolysis have been rarely reported, but toxic effects of statins could not be completely ruled… read more here.
Keywords: ranolazine; induced lipid; head drop; ranolazine induced ... See more keywords
Pharmacologic modulation of intracellular Na+ concentration with ranolazine impacts inflammatory response in humans and mice
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2207020119
Abstract: Significance Inflammation is a key process accompanying cardiovascular disease. Reducing inflammation is therefore an important therapeutic option. We provide evidence, that Na+ and Ca2+ modulation regulate the inflammatory response. Reducing intracellular Na+ pharmacologically using the… read more here.
Keywords: inflammation; modulation; inflammatory response; ranolazine ... See more keywords
A fatal ranolazine overdose after an intentional ingestion
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DOI: 10.1080/15563650.2019.1618465
Abstract: Ranolazine is an antianginal agent with a favorable safety profile [1]. We report a fatal ranolazine overdose. Forty-five minutes prior to hospitalization, a 65-year old woman with Turner’s syndrome and schizoaffective disorder reported ingestion of… read more here.
Keywords: ranolazine; fatal ranolazine; ranolazine overdose; ingestion ... See more keywords
[PP.22.03] IMPROVEMENT OF HYPERTENSION INDUCED HFPEF BY INHIBITION OF LATE SODIUM-INFLUX AND MAGNESIUM
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Hypertension"
DOI: 10.1097/01.hjh.0000523809.44295.38
Abstract: Objective: Heart insufficiency with preserved ejection fraction -HFpEF- (or diastolic Relaxation disorder) is a consequence of left ventricular dysfunction induced by a long-term hypertension. It is observed as well despite effective treatment with antihypertensive drugs.… read more here.
Keywords: ranolazine; relaxation disorder; treatment; diastolic relaxation ... See more keywords
Efficacy of nicorandil and ranolazine in prevention of contrast-induced nephropathy in patients with mild-to-moderate renal dysfunction: a randomized controlled trial
Sign Up to like & getrecommendations! Published in 2024 at "Coronary Artery Disease"
DOI: 10.1097/mca.0000000000001347
Abstract: Introduction Contrast-induced nephropathy (CIN) is a common complication after percutaneous coronary intervention (PCI). There is conflicting evidence regarding efficacy of nicorandil in CIN prevention. With respect to ranolazine, there is physiological possibility as well as… read more here.
Keywords: contrast; nicorandil ranolazine; efficacy nicorandil; ranolazine ... See more keywords