Digitalis Promotes Ventricular Arrhythmias in Flecainide- and Ranolazine-Pretreated Hearts
Sign Up to like & getrecommendations! Published in 2018 at "Cardiovascular Toxicology"
DOI: 10.1007/s12012-018-9494-7
Abstract: A post hoc analysis of the PALLAS trial suggested life-threatening interactions of digitalis and dronedarone. Thus, there is concern about an interplay between digitalis and other drugs that influence cardiac electrophysiology. We therefore investigated the… read more here.
Keywords: iqr; ranolazine; iqr erp; digitalis promotes ... See more keywords
Response to letter regarding article, "Effects of the antianginal drugs ranolazine, nicorandil and ivabradine on coronary microvascular function in patients with non-obstructive coronary artery disease: a meta-analysis of randomized controlled trials".
Sign Up to like & getrecommendations! Published in 2020 at "Clinical therapeutics"
DOI: 10.1016/j.clinthera.2019.12.016
Abstract: We thank Dr. Tolunay for expanding our point regarding the effect of ranolazine on chest pain in patients with coronary microcirculation dysfunction from our recent meta-analysis (Effects of the Antianginal Drugs Ranolazine, Nicorandil, and Ivabradine… read more here.
Keywords: antianginal drugs; ranolazine; effects antianginal; meta analysis ... See more keywords
Comparison of Pharmacokinetics and Safety of Ranolazine PR between Koreans and Caucasians.
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DOI: 10.1016/j.clinthera.2021.01.005
Abstract: PURPOSE Ranolazine, an inhibitor of late inward sodium current, is an antianginal agent. In this study, the pharmacokinetic (PK) properties and tolerability of single- and multiple-dose ranolazine were compared between healthy Koreans and Caucasians. METHODS… read more here.
Keywords: ranolazine; difference; koreans caucasians; safety ... See more keywords
Ranolazine for rhythm control in atrial fibrillation: A systematic review and meta-analysis.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2016.11.103
Abstract: BACKGROUND/OBJECTIVES Available pharmacological options for rhythm control strategy in atrial fibrillation (AF) are limited by sub-optimal efficacy and potentially serious adverse events. The aim of the present meta-analysis is to determine the efficacy and safety… read more here.
Keywords: rhythm control; control; ranolazine; meta analysis ... See more keywords
Ranolazine in patients with type 2 diabetes and chronic angina: A cost-effectiveness analysis and assessment of health-related quality-of-life.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2018.09.060
Abstract: BACKGROUND Type 2 diabetes (T2D) is associated with a high burden of angina. Ranolazine has been shown to reduce angina frequency versus placebo in patients with T2D and stable angina. We sought to estimate the… read more here.
Keywords: ranolazine; angina; cost; type diabetes ... See more keywords
Development of ethosomal gel of ranolazine for improved topical delivery: In vitro and ex vivo evaluation
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DOI: 10.1016/j.molliq.2016.11.114
Abstract: Abstract Ranolazine loaded ethosomal system were developed by varying the proportion of soya lecithin (0.9–1.5% w/v) and ethanol (20–40% w/v). The prepared ethosomal formulations (RET1-RET9) were evaluated in vitro for vesicle shape and size, zeta… read more here.
Keywords: ranolazine; vivo; ethosomal gel; delivery ... See more keywords
Ranolazine-induced lipid storage myopathy presenting with respiratory failure and head drop
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DOI: 10.1016/j.nmd.2021.03.004
Abstract: Ranolazine is an anti-ischemic drug often used along with statins in patients with ischemic heart disease. Ranolazine-induced proximal myopathy or rhabdomyolysis have been rarely reported, but toxic effects of statins could not be completely ruled… read more here.
Keywords: ranolazine; induced lipid; head drop; ranolazine induced ... See more keywords
Pharmacologic modulation of intracellular Na+ concentration with ranolazine impacts inflammatory response in humans and mice
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2207020119
Abstract: Significance Inflammation is a key process accompanying cardiovascular disease. Reducing inflammation is therefore an important therapeutic option. We provide evidence, that Na+ and Ca2+ modulation regulate the inflammatory response. Reducing intracellular Na+ pharmacologically using the… read more here.
Keywords: inflammation; modulation; inflammatory response; ranolazine ... See more keywords
A fatal ranolazine overdose after an intentional ingestion
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DOI: 10.1080/15563650.2019.1618465
Abstract: Ranolazine is an antianginal agent with a favorable safety profile [1]. We report a fatal ranolazine overdose. Forty-five minutes prior to hospitalization, a 65-year old woman with Turner’s syndrome and schizoaffective disorder reported ingestion of… read more here.
Keywords: ranolazine; fatal ranolazine; ranolazine overdose; ingestion ... See more keywords
[PP.22.03] IMPROVEMENT OF HYPERTENSION INDUCED HFPEF BY INHIBITION OF LATE SODIUM-INFLUX AND MAGNESIUM
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Hypertension"
DOI: 10.1097/01.hjh.0000523809.44295.38
Abstract: Objective: Heart insufficiency with preserved ejection fraction -HFpEF- (or diastolic Relaxation disorder) is a consequence of left ventricular dysfunction induced by a long-term hypertension. It is observed as well despite effective treatment with antihypertensive drugs.… read more here.
Keywords: ranolazine; relaxation disorder; treatment; diastolic relaxation ... See more keywords
Dabigatran-Associated Thrombocytopenia.
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Therapeutics"
DOI: 10.1097/mjt.0000000000000714
Abstract: function.4,5 To our knowledge, there have been 2 reports of severe neurological dysfunction with ranolazine.4,5 One case of an 81-year-old woman with renal dysfunction (creatinine clearance ,30 mL/min/1.73 m2) experienced neurological symptoms including hallucinations, dysarthria,… read more here.
Keywords: ranolazine; side effects; age; dysfunction ... See more keywords