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   Articles with "rap1" as a keyword



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Mutational analysis identifies functional Rap1, Su(Hw), and CTCF insulator sites in Arabidopsis thaliana.

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recommendations! Published in 2020 at "Plant cell reports"

DOI: 10.1007/s00299-020-02601-4

Abstract: KEY MESSAGE Genetic analysis identifies multiple, potential protein binding sites important for insulator function in Arabidopsis thaliana: Rap1 site in UASrpg, Su(Hw) site in UASrpg, and CTCF site in BEAD1c. Three non-plant insulators UASrpg, BEAD1c,… read more here.

Keywords: analysis identifies; arabidopsis thaliana; site; rap1 ... See more keywords
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Shank2 Binds to aPKC and Controls Tight Junction Formation with Rap1 Signaling during Establishment of Epithelial Cell Polarity.

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recommendations! Published in 2020 at "Cell reports"

DOI: 10.1016/j.celrep.2020.02.088

Abstract: Epithelial cells establish apicobasal polarity by forming tight junctions (TJs) at the apical-lateral boundary, which play fundamental roles in physiological functions. An evolutionarily conserved atypical protein kinase C (aPKC)-partitioning defective (PAR) complex functions as a… read more here.

Keywords: cell polarity; polarity; rap1; shank2 binds ... See more keywords
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Chromatin Fiber Invasion and Nucleosome Displacement by the Rap1 Transcription Factor

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recommendations! Published in 2019 at "Molecular Cell"

DOI: 10.1016/j.molcel.2019.10.025

Abstract: Summary Pioneer transcription factors (pTFs) bind to target sites within compact chromatin, initiating chromatin remodeling and controlling the recruitment of downstream factors. The mechanisms by which pTFs overcome the chromatin barrier are not well understood.… read more here.

Keywords: chromatin; transcription factor; chromatin fiber; rap1 ... See more keywords
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Either Rap1 or Cdc13 can protect telomeric single-stranded 3′ overhangs from degradation in vitro

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recommendations! Published in 2019 at "Scientific Reports"

DOI: 10.1038/s41598-019-55482-3

Abstract: Telomeres, the DNA-protein structures capping the ends of linear chromosomes, are important for regulating replicative senescence and maintaining genome stability. Telomeres consist of G-rich repetitive sequences that end in a G-rich single-stranded (ss) 3′ overhang,… read more here.

Keywords: single stranded; degradation; either rap1; rap1 ... See more keywords
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Dissection of α4β7 integrin regulation by Rap1 using novel conformation-specific monoclonal anti-β7 antibodies

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recommendations! Published in 2020 at "Scientific Reports"

DOI: 10.1038/s41598-020-70111-0

Abstract: Integrin activation is associated with conformational regulation. In this study, we developed a system to evaluate conformational changes in α4β7 integrin. We first inserted the PA tag into the plexin-semaphorin-integrin (PSI) domain of β7 chain,… read more here.

Keywords: integrin regulation; regulation rap1; conformation; rap1 ... See more keywords
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Rap1 regulates apical contractility to allow embryonic morphogenesis without tissue disruption and acts in part via Canoe-independent mechanisms

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recommendations! Published in 2022 at "Molecular Biology of the Cell"

DOI: 10.1091/mbc.e22-05-0176

Abstract: Embryonic morphogenesis is powered by dramatic changes in cell shape and arrangement driven by the cytoskeleton and its connections to adherens junctions. This requires robust linkage allowing morphogenesis without disrupting tissue integrity. The small GTPase… read more here.

Keywords: morphogenesis; canoe; morphogenesis without; rap1 ... See more keywords
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Trypanosoma brucei RAP1 Has Essential Functional Domains That Are Required for Different Protein Interactions

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recommendations! Published in 2020 at "mSphere"

DOI: 10.1128/msphere.00027-20

Abstract: Trypanosoma brucei causes human African trypanosomiasis and regularly switches its major surface antigen, VSG, to evade the host immune response. VSGs are expressed from subtelomeres in a monoallelic fashion. TbRAP1, a telomere protein, is essential… read more here.

Keywords: interaction; tbrap1; rap1; functional domains ... See more keywords
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Differential Use of Rap1 Effectors for Integrin Activation in Platelets and Lymphocytes

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recommendations! Published in 2020 at "Blood"

DOI: 10.1182/blood-2020-142720

Abstract: Rap1 is a major convergence point of the platelet and lymphocyte signaling pathways that result in talin1 binding to the integrin β-cytoplasmic domain and consequent integrin activation, effective hemostasis and immune functions. The nature of… read more here.

Keywords: integrin activation; r35e r118e; rap1; activation ... See more keywords
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Talin1 is the Principal Platelet Rap1 Effector of Integrin Activation.

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recommendations! Published in 2020 at "Blood"

DOI: 10.1182/blood.2020005348

Abstract: Rap1 is a major convergence point of the platelet signaling pathways that result in talin1 binding to the integrin b cytoplasmic domain and consequent integrin activation, platelet aggregation, and effective hemostasis. The nature of the… read more here.

Keywords: talin1 principal; platelet; rap1; integrin activation ... See more keywords
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Applied stretch initiates directional invasion through the action of Rap1 GTPase as a tension sensor

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recommendations! Published in 2017 at "Journal of Cell Science"

DOI: 10.1242/jcs.180612

Abstract: ABSTRACT Although it is known that a stiffening of the stroma and the rearrangement of collagen fibers within the extracellular matrix facilitate the movement of tumor cells away from the primary lesion, the underlying mechanisms… read more here.

Keywords: invasion; tumor cells; applied stretch; rap1 ... See more keywords
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Rap1B promotes VEGF-induced endothelial permeability and is required for dynamic regulation of the endothelial barrier

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recommendations! Published in 2018 at "Journal of Cell Science"

DOI: 10.1242/jcs.207605

Abstract: ABSTRACT Vascular endothelial growth factor (VEGF), a key angiogenic and permeability factor, plays an important role in new blood vessel formation. However, abnormal VEGF-induced VEGFR2 signaling leads to hyperpermeability. We have shown previously that Rap1,… read more here.

Keywords: cell; endothelial barrier; vegf induced; permeability ... See more keywords