Activation of the Epac/Rap1 signaling pathway alleviates blood-brain barrier disruption and brain damage following cerebral ischemia/reperfusion injury.
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DOI: 10.2139/ssrn.4361230
Abstract: Blood brain barrier (BBB) destruction plays a key role in ischemia stroke, including promoting BBB leakage and brain edema, and leads to unfavorable patient prognosis. Epac/Rap1 signaling pathway is important in mediating endothelial cell barrier… read more here.
Keywords: signaling pathway; barrier; brain; epac rap1 ... See more keywords