Modifying Rap1-signalling by targeting Pde6δ is neuroprotective in models of Alzheimer’s disease
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DOI: 10.1186/s13024-018-0283-3
Abstract: BackgroundNeuronal Ca2+ dyshomeostasis and hyperactivity play a central role in Alzheimer’s disease pathology and progression. Amyloid-beta together with non-genetic risk-factors of Alzheimer’s disease contributes to increased Ca2+ influx and aberrant neuronal activity, which accelerates neurodegeneration… read more here.
Keywords: rap1 signalling; alzheimer disease; disease; ca2 ... See more keywords