Novel roles for podocalyxin in regulating stress myelopoiesis, Rap1a, and neutrophil migration.
Sign Up to like & getrecommendations! Published in 2017 at "Experimental hematology"
DOI: 10.1016/j.exphem.2017.04.001
Abstract: Podocalyxin (Podxl) is a CD34 orthologue and cell surface sialomucin reported to have roles in renal podocyte diaphragm slit development; vascular cell integrity; and the progression of blood, breast, and prostate cancers. Roles for Podxl… read more here.
Keywords: novel roles; rap1a; stress; podxl ... See more keywords
Optimal Inhibition of Choroidal Neovascularization by scAAV2 with VMD2 Promoter-driven Active Rap1a in the RPE
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-52163-z
Abstract: Age-related macular degeneration (AMD) is a multifactorial chronic disease that requires long term treatment. Gene therapy is being considered as a promising tool to treat AMD. We found that increased activation of Rap1a in the… read more here.
Keywords: rap1a rpe; active rap1a; scaav2 vmd2; rap1a ... See more keywords
Rap1 Guanosine Triphosphate Hydrolase (GTPase) Regulates Shear Stress-Mediated Adhesion of Mesenchymal Stromal Cells
Sign Up to like & getrecommendations! Published in 2025 at "Biology"
DOI: 10.3390/biology14010096
Abstract: Simple Summary Rap1 has been implicated in the migration regulation of mesenchymal stem cells (MSCs). We found both Rap1A and Rap1B mRNAs expressed in human MSCs and suppressed their expression using siRNAs against both isoforms.… read more here.
Keywords: shear stress; adhesion; guanosine triphosphate; rap1a ... See more keywords