Rap2a serves as a potential prognostic indicator of renal cell carcinoma and promotes its migration and invasion through up-regulating p-Akt
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-06162-7
Abstract: Rap2a, a member of the small GTPase superfamily, belongs to Ras superfamily, and its function in cancer progression is still poorly understood. Our previous study indicated that the ectopic expression of Rap2a enhanced the migration… read more here.
Keywords: cell; rcc; migration invasion; rap2a ... See more keywords
miR-33a-5p Targets RAP2A to Mediate the Sensitivity of Gastric Cancer Cells to 5-FU
Sign Up to like & getrecommendations! Published in 2022 at "Disease Markers"
DOI: 10.1155/2022/9701047
Abstract: Objective The objective of this study is to explore the effects of microRNA-33a-5p (miR-33a-5p)-ras-related protein Rap-2a (RAP2A) on biological functions of gastric cancer (GC) and to find the potential functional mechanism. Methods We measured the… read more here.
Keywords: cell; mir 33a; sensitivity; gastric cancer ... See more keywords
Loss of RAP2A Aggravates Cartilage Degradation in TMJOA via YAP Signaling
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Dental Research"
DOI: 10.1177/00220345221132213
Abstract: Abnormal stress loading has been considered a major contributor to the initiation of temporomandibular joint osteoarthritis (TMJOA), but studies to date have not identified a functional molecule that transforms physical stress into biological or biochemical… read more here.
Keywords: loss rap2a; tmjoa; cartilage degradation; yap ... See more keywords
Rap2A/p-ERK1/2 is involved in glioma proliferation and migration.
Sign Up to like & getrecommendations! Published in 2022 at "Current molecular medicine"
DOI: 10.2174/1566524022666220804152049
Abstract: BACKGROUND Gliomas, the most common and malignant primary tumors, relate to the highest mortality rate of all central nervous system cancers. Previously, it has been demonstrated that Rap2A plays an essential role in tumor growth… read more here.
Keywords: cell; proliferation migration; rap2a; glioma ... See more keywords
Abnormal expression of Rap2A as a prognostic marker for human breast cancer.
Sign Up to like & getrecommendations! Published in 2020 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202009_23039
Abstract: OBJECTIVE The aim of this study was to explore the expression of GTPase protein Ras-related protein Rap-2a (Rap2A) in breast cancer (BC). Furthermore, the associations of Rap2A with clinicopathological parameters of BC patients were investigated.… read more here.
Keywords: expression; expression rap2a; rap2a; breast cancer ... See more keywords
LINC00319-Mediated miR-3127 Repression Enhances Bladder Cancer Progression Through Upregulation of RAP2A
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2020.00180
Abstract: Recent studies suggested that microRNA-3127 (miR-3127) was dysregulated in multiple tumor types and has important roles in tumorigenesis and cancer progression. However, its biological roles and the mechanisms that regulate its expression in bladder cancer… read more here.
Keywords: bca; linc00319; expression; rap2a ... See more keywords
lncRNA FLVCR1-AS1 drives colorectal cancer progression via modulation of the miR-381/RAP2A axis
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2020.11778
Abstract: Colorectal cancer (CRC) is one of the most prevalent types of cancer globally. Long non-coding RNAs (lncRNAs) have been suggested to serve as vital regulators in CRC. lncRNA feline leukemia virus subgroup C receptor 1… read more here.
Keywords: mir 381; as1; flvcr1 as1; rap2a ... See more keywords