Efficacy and Safety of Topical Rapamycin in Patients With Facial Angiofibromas Secondary to Tuberous Sclerosis Complex: The TREATMENT Randomized Clinical Trial
Sign Up to like & getrecommendations! Published in 2018 at "JAMA Dermatology"
DOI: 10.1001/jamadermatol.2018.0464
Abstract: Importance Facial angiofibromas occur in approximately 75% of individuals with tuberous sclerosis complex (TSC), causing substantial morbidity and disfigurement. Current therapies are partially effective, uncomfortable, produce scarring, and need repeating to treat recurrence. Objective To… read more here.
Keywords: topical rapamycin; trial; vehicle; group ... See more keywords
Engineering a Rapid Insulin Release System Controlled By Oral Drug Administration
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202105619
Abstract: Abstract Rapid insulin release plays an essential role in maintaining blood‐glucose homeostasis in mammalians. Patients diagnosed with type‐I diabetes mellitus experience chronic and remarkably high blood‐sugar levels, and require lifelong insulin injection therapy, so there… read more here.
Keywords: insulin release; rapid insulin; rapamycin; release ... See more keywords
Exosomes derived from rapamycin-treated 4T1 breast cancer cells induced polarization of macrophages to M1 phenotype.
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology and applied biochemistry"
DOI: 10.1002/bab.2473
Abstract: M2 macrophages are the most prevalent type in the tumor microenvironment and their polarization to M1 type can be used as a potential cancer immunotherapy. Here, we investigated the role of tumor microenvironment and particularly… read more here.
Keywords: microscopy; breast cancer; rapamycin; polarization ... See more keywords
Rapamycin enhances growth inhibition on urothelial carcinoma cells through LKB1 deficiency‐mediated mitochondrial dysregulation
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27979
Abstract: Rapamycin, a mammalian target of rapamycin (mTOR) inhibitor, has significant potential for application in the treatment of urothelial carcinoma (URCa) of the bladder. Previous studies have shown that regulation of the AMP‐activated serine/threonine protein kinase… read more here.
Keywords: growth inhibition; urothelial carcinoma; urca cells; lkb1 deficiency ... See more keywords
Rapamycin encourages the maintenance of mitochondrial dynamic balance and mitophagy activity for improving developmental competence of blastocysts in porcine embryos in vitro
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Reproduction and Development"
DOI: 10.1002/mrd.23681
Abstract: Rapamycin induces autophagosome formation and activity during oocyte maturation, improved fertilization ability of matured oocytes, and early embryonic developmental competence. However, potential changes in mitochondrial fission and mitophagy via regulation of autophagy in early porcine… read more here.
Keywords: porcine embryos; mitochondrial fission; rapamycin; activity ... See more keywords
The effect of the mTOR inhibitor rapamycin on glucoCEST signal in a preclinical model of glioblastoma
Sign Up to like & getrecommendations! Published in 2019 at "Magnetic Resonance in Medicine"
DOI: 10.1002/mrm.27683
Abstract: The mammalian target of rapamycin is an enzyme that regulates cell metabolism and proliferation. It is up‐regulated in aggressive tumors, such as glioblastoma, leading to increased glucose uptake and consumption. It has been suggested that… read more here.
Keywords: effect mtor; inhibitor rapamycin; mtor inhibitor; rapamycin glucocest ... See more keywords
Development of a fluorescent three‐hybrid system for the identification of protein‐protein associators
Sign Up to like & getrecommendations! Published in 2020 at "Peptide Science"
DOI: 10.1002/pep2.24178
Abstract: The chemically‐induced dimerization of proteins is fundamental to many key regulatory pathways. A number of natural products exert their downstream effect through the stabilization of a protein complex, either by direct binding to two distinct… read more here.
Keywords: protein; hybrid system; system; three hybrid ... See more keywords
Short- and long-term effects of rapamycin on ischemic damage and apoptotic changes in torsion of rat testes
Sign Up to like & getrecommendations! Published in 2020 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-020-01965-4
Abstract: Rapamycin has antioxidant defense mechanisms and immune suppressive effects. To detect the short- and long-term effects of rapamycin on ischemic damage and apoptotic changes in torsion of rat testes, mature male albino Wistar rats (… read more here.
Keywords: term; long term; effects rapamycin; short long ... See more keywords
Lactobacillus casei protects dextran sodium sulfate- or rapamycin-induced colonic inflammation in the mouse
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Nutrition"
DOI: 10.1007/s00394-019-02001-9
Abstract: PurposeHuman colon inflammation is associated with changes in the diverse and abundant microorganisms in the gut. As important beneficial microbes, Lactobacillus contributes to the immune responses and intestinal integrity that may alleviate experimental colitis. However,… read more here.
Keywords: lactobacillus casei; rapamycin induced; sulfate rapamycin; inflammation ... See more keywords
Rapamycin Alleviates Hypertriglyceridemia-Related Acute Pancreatitis via Restoring Autophagy Flux and Inhibiting Endoplasmic Reticulum Stress
Sign Up to like & getrecommendations! Published in 2020 at "Inflammation"
DOI: 10.1007/s10753-020-01228-7
Abstract: Hypertriglyceridemia (HTG) can aggravate acute pancreatitis (AP), but its pathogenesis remains unclear. As autophagic activity is closely related to lipid metabolism and AP, we investigated the autophagic response in models of AP aggravated by HTG… read more here.
Keywords: acute pancreatitis; endoplasmic reticulum; flux; stress ... See more keywords
Report of a Chinese Cohort with Activated Phosphoinositide 3-Kinase δ Syndrome
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Immunology"
DOI: 10.1007/s10875-018-0568-x
Abstract: PurposeWe aimed to report the clinical manifestations and immunological features of activated phosphatidylinositol 3-kinase δ syndrome 1 (APDS1) in a Chinese cohort. Moreover, we investigated the efficacy and safety of rapamycin therapy for Chinese patients… read more here.
Keywords: kinase syndrome; report; rapamycin; chinese cohort ... See more keywords