Antitumor Synergism and Enhanced Survival with a Tumor Vasculature–Targeted Enzyme Prodrug System, Rapamycin, and Cyclophosphamide
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DOI: 10.1158/1535-7163.mct-16-0263
Abstract: Mutant cystathionine gamma-lyase was targeted to phosphatidylserine exposed on tumor vasculature through fusion with Annexin A1 or Annexin A5. Cystathionine gamma-lyase E58N, R118L, and E338N mutations impart nonnative methionine gamma-lyase activity, resulting in tumor-localized generation… read more here.
Keywords: vasculature targeted; enzyme prodrug; tumor vasculature; rapamycin cyclophosphamide ... See more keywords