Progress on the efficacy and potential mechanisms of rapamycin in the treatment of immune thrombocytopenia
Sign Up to like & getrecommendations! Published in 2022 at "Hematology"
DOI: 10.1080/16078454.2022.2151230
Abstract: ABSTRACT Objective The complex pathogenesis of relapsed and refractory (R/R) immune thrombocytopenia (ITP) contributes to the varied efficacy and tolerability of current treatment regimens. Rapamycin, an immunomodulatory agent, was originally used in the prevention of… read more here.
Keywords: immune thrombocytopenia; rapamycin treatment; immune; itp ... See more keywords
Modulation of nonsense mediated decay by rapamycin
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DOI: 10.1093/nar/gkw1109
Abstract: Abstract Rapamycin is a naturally occurring macrolide whose target is at the core of nutrient and stress regulation in a wide range of species. Despite well-established roles as an inhibitor of cap-dependent mRNA translation, relatively… read more here.
Keywords: rapamycin treatment; modulation nonsense; ptc containing; rapamycin ... See more keywords
Short‐term rapamycin treatment increases ovarian lifespan in young and middle‐aged female mice
Sign Up to like & getrecommendations! Published in 2017 at "Aging Cell"
DOI: 10.1111/acel.12617
Abstract: Although age‐related ovarian failure in female mammals cannot be reversed, recent strategies have focused on improving reproductive capacity with age, and rapamycin is one such intervention that has shown a potential for preserving the ovarian… read more here.
Keywords: rapamycin treatment; treatment; ovarian lifespan; term ... See more keywords
Rapamycin Treatment Reduces Acute Myocarditis Induced by Trypanosoma cruzi Infection
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DOI: 10.1159/000504322
Abstract: Chagas disease affects millions of people mainly in Latin America and is a protozoan illness caused by the parasite Trypanosoma cruzi. Chagasic cardiomyopathy is the leading cause of mortality of infected patients, due to compromised… read more here.
Keywords: rapamycin treatment; infection; trypanosoma cruzi; myocarditis ... See more keywords
A brain proteomic investigation of rapamycin effects in the Tsc1+/− mouse model
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Autism"
DOI: 10.1186/s13229-017-0151-y
Abstract: BackgroundTuberous sclerosis complex (TSC) is a rare monogenic disorder characterized by benign tumors in multiple organs as well as a high prevalence of epilepsy, intellectual disability and autism. TSC is caused by inactivating mutations in… read more here.
Keywords: rapamycin treatment; tsc1 mice; treatment; brain ... See more keywords
Transient rapamycin treatment during developmental stage extends lifespan in Mus musculus and Drosophila melanogaster
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DOI: 10.15252/embr.202255299
Abstract: Lifespan is determined by complex and tangled mechanisms that are largely unknown. The early postnatal stage has been proposed to play a role in lifespan, but its contribution is still controversial. Here, we show that… read more here.
Keywords: rapamycin treatment; mus musculus; lifespan mus; drosophila ... See more keywords
MicroRNA Expression Profile in TSC Cell Lines and the Impact of mTOR Inhibitor
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232214493
Abstract: The aim of this study was to assess the potential implication of microRNA on tuberous sclerosis (TSC) pathogenesis by performing microRNA profiling on cell lines silencing TSC1 or TSC2 genes using qPCR panels, before and… read more here.
Keywords: tsc; rapamycin treatment; expression; cell lines ... See more keywords
LncRP11-675F6.3 responds to rapamycin treatment and reduces triglyceride accumulation via interacting with HK1 in hepatocytes by regulating autophagy and VLDL-related proteins.
Sign Up to like & getrecommendations! Published in 2023 at "Acta biochimica et biophysica Sinica"
DOI: 10.3724/abbs.2023091
Abstract: Long noncoding RNAs (lncRNAs) have been widely proven to be involved in liver lipid homeostasis. Herein, we identify an upregulated lncRNA named lncRP11-675F6.3 in response to rapamycin treatment using a microarray in HepG2 cells. Knockdown… read more here.
Keywords: rapamycin treatment; triglyceride accumulation; vldl; hk1 ... See more keywords