Anatomical and neurochemical organization of the serotonergic system in the mammalian brain and in particular the involvement of the dorsal raphe nucleus in relation to neurological diseases.
Sign Up to like & getrecommendations! Published in 2021 at "Progress in brain research"
DOI: 10.1016/bs.pbr.2021.02.003
Abstract: The brainstem is a neglected brain area in neurodegenerative diseases, including Alzheimer's and Parkinson's disease, frontotemporal lobar degeneration and autonomic dysfunction. In Depression, several observations have been made in relation to changes in one particular… read more here.
Keywords: raphe nucleus; area; relation; dorsal raphe ... See more keywords
The effects of local microinjection of selective dopamine D1 and D2 receptor agonists and antagonists into the dorsal raphe nucleus on sleep and wakefulness in the rat
Sign Up to like & getrecommendations! Published in 2018 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2017.11.006
Abstract: HIGHLIGHTSMicroinjection of SKF38393, bromocriptine and quinpirole into the DRN reduced REMS.Bromocriptine and quinpirole increased, in addition, wakefulness.The DAergic system plays a role in the regulation of the 5‐HT system. ABSTRACT The effects of the dopamine… read more here.
Keywords: raphe nucleus; dorsal raphe; receptor agonists; dopamine receptor ... See more keywords
Estrogen Withdrawal Increases Postpartum Anxiety via Oxytocin Plasticity in the Paraventricular Hypothalamus and Dorsal Raphe Nucleus
Sign Up to like & getrecommendations! Published in 2021 at "Biological Psychiatry"
DOI: 10.1016/j.biopsych.2020.11.016
Abstract: BACKGROUND Estrogen increases dramatically during pregnancy but quickly drops below prepregnancy levels at birth and remains suppressed during the postpartum period. Clinical and rodent work suggests that this postpartum drop in estrogen results in an… read more here.
Keywords: raphe nucleus; anxiety; estrogen withdrawal; estrogen ... See more keywords
Serotonin2B receptors in the rat dorsal raphe nucleus exert a GABA-mediated tonic inhibitory control on serotonin neurons
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2018.09.015
Abstract: &NA; The central serotonin2B receptor (5‐HT2BR) is a well‐established modulator of dopamine (DA) neuron activity in the rodent brain. Recent studies in rats have shown that the effect of 5‐HT2BR antagonists on accumbal and medial… read more here.
Keywords: raphe nucleus; drn; control; tonic inhibitory ... See more keywords
The modulation of the spatial reference memory by the orexinergic system of the dorsal raphe nucleus.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.118777
Abstract: The dorsal raphe nucleus (DRN) is a brainstem nucleus involved in the pathophysiology of the depression, through its serotoninergic innervation. Furthermore, depressive symptoms in patients are also associated with some memory and sleep complaints. Anatomical… read more here.
Keywords: orexin; raphe nucleus; spatial reference; reference memory ... See more keywords
Glutamatergic Signals in the Dorsal Raphe Nucleus Regulate Maternal Aggression and Care in an Opposing Manner in Mice
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DOI: 10.1016/j.neuroscience.2018.12.034
Abstract: Lactating female mice nurture their pups and attack intruders in their territory. When an intruder invades a dam's territory, she needs to switch her behavior from care to aggression to protect her pups and territory.… read more here.
Keywords: glutamatergic signals; raphe nucleus; nurturing behavior; aggression ... See more keywords
Chemogenetic inhibition of lateral habenula projections to the dorsal raphe nucleus reduces passive coping and perseverative reward seeking in rats
Sign Up to like & getrecommendations! Published in 2020 at "Neuropsychopharmacology"
DOI: 10.1038/s41386-020-0616-0
Abstract: The lateral habenula (LHb) processes information about aversive experiences that contributes to the symptoms of stress disorders. Previously, we found that chemogenetic inhibition of rat LHb neurons reduced immobility in the forced swim test, but… read more here.
Keywords: lhb neurons; raphe nucleus; inhibition; dorsal raphe ... See more keywords
Physiological dosages of estradiol and diarylpropionitrile decrease depressive behavior and increase tryptophan hydroxylase expression in the dorsal raphe nucleus of rats subjected to the forced swim test
Sign Up to like & getrecommendations! Published in 2019 at "NeuroReport"
DOI: 10.1097/wnr.0000000000001158
Abstract: The dorsal raphe nucleus (DR) is a crucial source of serotonin (5-HT) neurons involved in the regulation of stress-induced depression. Estrogen receptors have been identified in the DR, yet the role of estrogen in modulating… read more here.
Keywords: expression; mgr; receptor; estrogen ... See more keywords
Serotonin hyperpolarizes the dorsal raphe nucleus neurons of mice by activating G protein–coupled inward rectifier potassium channels
Sign Up to like & getrecommendations! Published in 2020 at "NeuroReport"
DOI: 10.1097/wnr.0000000000001501
Abstract: Serotonin (5-HT) has an important role in the pathophysiology of the mood disorders like major depression and anxiety disorders in central nervous system. On the one hand, dorsal raphe nucleus (DRN) neurons send serotonergic projections… read more here.
Keywords: potassium; neurons mice; drn neurons; dorsal raphe ... See more keywords
The effect of activating serotonergic neurons in the dorsal raphe nucleus on control of vigilance state
Sign Up to like & getrecommendations! Published in 2017 at "European Respiratory Journal"
DOI: 10.1183/1393003.congress-2017.oa1753
Abstract: Based on results from genetic, neuropharmacological and electrophysiological studies, serotonin (5-HT) neurons in the dorsal raphe nucleus (DRN) apparently function predominantly to promote wakefulness and inhibit REM sleep. However, the effects of 5-HT on sleep… read more here.
Keywords: state; raphe nucleus; vigilance state; neurons dorsal ... See more keywords
Dorsal raphe nucleus to anterior cingulate cortex 5-HTergic neural circuit modulates consolation and sociability
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DOI: 10.7554/elife.67638
Abstract: Consolation is a common response to the distress of others in humans and some social animals, but the neural mechanisms underlying this behavior are not well characterized. By using socially monogamous mandarin voles, we found… read more here.
Keywords: cingulate cortex; dorsal raphe; sociability; consolation ... See more keywords