Rapid Access to Bi‐ and Tri‐Functionalized Dibenzofurans and their Application in Selective Suzuki–Miyaura Cross Coupling Reactions
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.201801286
Abstract: Syntheses of 1,2-, 1,3-, 1,4-, 1,8-, 2,4-, 3,4-, 4,8-, 1,2,4-, 1,2,8- and 1,3,4-functionalized dibenzofurans in few steps with good to excellent yields starting from dibenzofuran-1-ol or -4-ol are presented. These rapidly accessible bi- or tri-functionalized… read more here.
Keywords: suzuki miyaura; functionalized dibenzofurans; tri functionalized; rapid access ... See more keywords
Clinical outcomes of patients discharged from the Rapid Access Chest Pain Clinic with non-anginal chest pain: A retrospective cohort study.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2019.12.008
Abstract: BACKGROUND The Rapid Access Chest Pain Clinic (RACPC) has become an important means of assessing patients who present with ischaemic or ischaemia-like symptoms of recent onset. Observations have shown that up to 70% are discharged… read more here.
Keywords: cardiology; chest; chest pain; rapid access ... See more keywords
RAPID ACCESS ARRHYTHMIA CLINICS VERSUS USUAL CARE: IMPROVING EFFICIENCY, SAFETY, AND COST EFFECTIVENESS OF ARRHYTHMIA MANAGEMENT
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American College of Cardiology"
DOI: 10.1016/s0735-1097(20)30929-3
Abstract: Rapid Access Arrhythmia Clinics (RAACs) have been proposed as a method to rapidly assess arrhythmias in the community and potentially reduce hospital burden. We describe a RAAC model of care, compare safety endpoints to usual… read more here.
Keywords: arrhythmia; access arrhythmia; rapid access; arrhythmia clinics ... See more keywords
Rapid Access to Kinase Inhibitor Pharmacophores by Regioselective C-H Arylation of Thieno[2,3-d]pyrimidine.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c00143
Abstract: Regioselective C-H arylations of thieno[2,3-d]pyrimidine are accomplished under palladium catalysis. Thieno[2,3-d]pyrimidines react with aryl iodides at the C6-position and with aryl boronic acids at the C5-position, showing excellent regioselectivity. Mechanistic investigations indicate that the regioselectivity… read more here.
Keywords: rapid access; kinase; pyrimidine; arylation ... See more keywords
Defluoroalkylation of Trifluoromethylarenes with Hydrazones: Rapid Access to Benzylic Difluoroarylethylamines
Sign Up to like & getrecommendations! Published in 2023 at "Organic Letters"
DOI: 10.1021/acs.orglett.3c00126
Abstract: Here, we report an efficient and modular approach toward the formation of difluorinated arylethylamines from simple aldehyde-derived N,N-dialkylhydrazones and trifluoromethylarenes (CF3-arenes). This method relies on selective C–F bond cleavage via reduction of the CF3-arene. We… read more here.
Keywords: defluoroalkylation trifluoromethylarenes; hydrazones rapid; trifluoromethylarenes hydrazones; rapid access ... See more keywords
Rapid access to cyclopentadiene derivatives through gold-catalyzed cycloisomerization of ynamides with cyclopropenes by preferential activation of alkenes over alkynes.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c7cc01368j
Abstract: In this communication, gold-catalyzed intermolecular cycloisomerization of cyclopropenes and ynamides is investigated. The current transformation displayed an activation priority of double bonds over triple bonds by the cationic gold catalyst, giving the corresponding cyclopentadienes in… read more here.
Keywords: rapid access; cycloisomerization; cyclopentadiene derivatives; activation ... See more keywords
Rapid access to sulfate-encapsulated symmetrical and asymmetrical capsules based on silver–pyrazole complex cations
Sign Up to like & getrecommendations! Published in 2019 at "New Journal of Chemistry"
DOI: 10.1039/c9nj02105a
Abstract: A new class of sulfate-encapsulated symmetrical and asymmetrical capsules is developed through ion-pair complexation. read more here.
Keywords: rapid access; asymmetrical capsules; encapsulated symmetrical; symmetrical asymmetrical ... See more keywords
Rapid access to 9-arylfluorene and spirobifluorene through Pd-catalysed C-H arylation/deaminative annulation.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc01355j
Abstract: We describe here a facile synthesis of 9-arylfluorenes and spirobifluorenes from readily available 1,1-diarylmethylamines and iodoarenes through Pd-cataylsed C(sp2)-H arylation and a sequential deaminative annulation. The reaction features high efficiency and simplicity of operation, constituting… read more here.
Keywords: rapid access; deaminative annulation; access arylfluorene; arylation ... See more keywords
Rapid access to organic triflates based on flash generation of unstable sulfonium triflates in flow.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc02344j
Abstract: Flash (extremely fast) electrochemical generation of unstable arylbis(arylthio)sulfonium triflates [ArS(ArSSAr)]+ [OTf]- that are unsuitable for accumulation in batch processes was achieved within 10 s in a divided-type flow electrochemcial reactor, enabling one-flow access to vinyl… read more here.
Keywords: generation unstable; sulfonium triflates; rapid access;
P020 Audit of bosentan use in Rapid Access to Digital Ulcer Clinic (RADUC) in systemic sclerosis: a single-centre experience
Sign Up to like & getrecommendations! Published in 2023 at "Rheumatology"
DOI: 10.1093/rheumatology/kead104.062
Abstract: Systemic sclerosis (SSc) is an autoimmune disease characterised by microvascular injury and excessive fibrotic responses. About 55% of SSc patients develop digital ulcers (DUs). The revised “Clinical commissioning policy for the prescription of sildenafil and… read more here.
Keywords: systemic sclerosis; bosentan; rapid access; dus ... See more keywords
G384(P) Introduction of a novel junior doctor -led prolonged jaundice clinic in order to reduce the wait time for rapid access clinic appointments within the paediatric department
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Disease in Childhood"
DOI: 10.1136/archdischild-2018-rcpch.373
Abstract: There has been an increasing demand for rapid access clinic appointments in the Paediatric department in Northampton General Hospital over the past 2 years, which has led to an increase in wait time for an… read more here.
Keywords: rapid access; prolonged jaundice; access clinic; junior doctor ... See more keywords