Comparison of acute treatment with delayed-onset versus rapid-acting antidepressants on effort-related choice behaviour
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DOI: 10.1007/s00213-020-05541-9
Abstract: Rationale Reward-related impairments are common in major depressive disorder (MDD) and may contribute to the loss of interest in pleasurable activities. A novel approach to studying reward-related decision-making are effort-based tasks; however, direct comparisons between… read more here.
Keywords: choice behaviour; rapid acting; effort; delayed onset ... See more keywords
Neurobiology of the Rapid-Acting Antidepressant Effects of Ketamine: Impact and Opportunities
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DOI: 10.1016/j.biopsych.2020.12.006
Abstract: The discovery of the rapid-acting antidepressant effects of ketamine has 1) led to a paradigm shift in our perception of what is possible in treating severe depression; 2) spurred a wave of basic, translation, and… read more here.
Keywords: rapid acting; pathology; effects ketamine; neurobiology ... See more keywords
Intranasal administration of transforming growth factor-β1 elicits rapid-acting antidepressant-like effects in a chronic social defeat stress model: A role of TrkB signaling
Sign Up to like & getrecommendations! Published in 2021 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2021.04.010
Abstract: (R,S)-ketamine causes rapid-acting and sustained antidepressant effects in treatment-resistant patients with depression although the precise molecular mechanisms underlying its antidepressant action remain unclear. We recently reported that transforming growth factor (TGF)-β1 might contribute to the… read more here.
Keywords: trkb signaling; rapid acting; like effects; intranasal administration ... See more keywords
Cognitive effects of rapid-acting treatments for resistant depression: Just adverse, or contributing to clinical efficacy?
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DOI: 10.1016/j.jpsychires.2021.06.026
Abstract: Major Depressive Disorder is a major public health problem and has a high rate of treatment resistance. Fear conditioning has been proposed as a potential mechanism sustaining negative affect in mood disorders. With the aim… read more here.
Keywords: rapid acting; efficacy; cognitive effects; treatments resistant ... See more keywords
A wake-up call: Sleep physiology and related translational discrepancies in studies of rapid-acting antidepressants
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DOI: 10.1016/j.pneurobio.2021.102140
Abstract: Depression is frequently associated with sleep problems, and clinical improvement often coincides with the normalization of sleep architecture and realignment of circadian rhythm. The effectiveness of treatments targeting sleep in depressed patients, such as sleep… read more here.
Keywords: wake call; acting antidepressants; rapid acting; physiology ... See more keywords
Efficacy and safety of Tregopil, a novel, ultra-rapid acting oral prandial insulin analog, as part of a basal-bolus regimen in type 2 diabetes: a randomized, active-controlled phase 2/3 study
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Pharmacotherapy"
DOI: 10.1080/14656566.2022.2141569
Abstract: ABSTRACT Background Efficacy and safety of ultra-rapid acting oral prandial insulin Tregopil was compared with insulin aspart (IAsp) in patients with type 2 diabetes (T2D) on insulin glargine and metformin. Research design and methods In… read more here.
Keywords: rapid acting; safety; iasp; tregopil ... See more keywords
Real-World Analysis of Rapid-Acting Insulin Analog Use and Its Blood Glucose Lowering Effect in Patients with Type 2 Diabetes Mellitus: Results from PASSION Disease Registry in Korea
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DOI: 10.2147/dmso.s334944
Abstract: Purpose Although rapid-acting insulins (RAIs) are used frequently in Korean clinical settings, evidence on their use is limited. This study explores the pattern and clinical effectiveness of the use of RAIs in Korean patients with… read more here.
Keywords: patients type; rapid acting; day; type diabetes ... See more keywords
Rapid-Acting Antidepressants.
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DOI: 10.2174/1381612824666180730104707
Abstract: BACKGROUND Conventional antidepressants are thought to produce their impact on clinical symptoms by increasing the central availability of biogenic amine neurotransmitters (the monoamine hypothesis of depression). These drugs continue to be the primary medicines used… read more here.
Keywords: acting antidepressants; rapid acting;
Molecular and Cellular Mechanisms of Rapid-Acting Antidepressants Ketamine and Scopolamine
Sign Up to like & getrecommendations! Published in 2017 at "Current Neuropharmacology"
DOI: 10.2174/1570159x14666160309114549
Abstract: Major depressive disorder (MDD) is a prevalent neuropsychiatric disease that causes profound social and economic burdens. The impact of MDD is compounded by the limited therapeutic efficacy and delay of weeks to months of currently… read more here.
Keywords: ketamine scopolamine; molecular cellular; cellular mechanisms; rapid acting ... See more keywords
1041-P: Randomized Controlled Trial on the Efficacy of Supplemental Rapid-Acting Insulin during Basal-Bolus Regimen in Non-ICU Patients with Type 2 Diabetes
Sign Up to like & getrecommendations! Published in 2020 at "Diabetes"
DOI: 10.2337/db20-1041-p
Abstract: The administration of rapid-acting insulin per sliding scale (SSI) for correction of hyperglycemia in non-ICU patients with type 2 diabetes (T2D) is used with most basal-bolus insulin (BBI) regimens; however, the safety and efficacy of… read more here.
Keywords: insulin; basal; rapid acting; non icu ... See more keywords
Methylone, a rapid acting entactogen with robust anxiolytic and antidepressant-like activity
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Psychiatry"
DOI: 10.3389/fpsyt.2022.1041277
Abstract: Introduction Selective serotonin reuptake inhibitor (SSRI) antidepressants represent first-line pharmacological treatment for a variety of neuropsychiatric illnesses, including major depressive disorder (MDD), anxiety, and post-traumatic stress disorder (PTSD), which show high rates of comorbidity. SSRIs… read more here.
Keywords: rapid acting; acting entactogen; methylone; antidepressant like ... See more keywords