Comparison of acute treatment with delayed-onset versus rapid-acting antidepressants on effort-related choice behaviour
Sign Up to like & getrecommendations! Published in 2020 at "Psychopharmacology"
DOI: 10.1007/s00213-020-05541-9
Abstract: Rationale Reward-related impairments are common in major depressive disorder (MDD) and may contribute to the loss of interest in pleasurable activities. A novel approach to studying reward-related decision-making are effort-based tasks; however, direct comparisons between… read more here.
Keywords: choice behaviour; rapid acting; effort; delayed onset ... See more keywords
Neurobiology of the Rapid-Acting Antidepressant Effects of Ketamine: Impact and Opportunities
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DOI: 10.1016/j.biopsych.2020.12.006
Abstract: The discovery of the rapid-acting antidepressant effects of ketamine has 1) led to a paradigm shift in our perception of what is possible in treating severe depression; 2) spurred a wave of basic, translation, and… read more here.
Keywords: rapid acting; pathology; effects ketamine; neurobiology ... See more keywords
Intranasal administration of transforming growth factor-β1 elicits rapid-acting antidepressant-like effects in a chronic social defeat stress model: A role of TrkB signaling
Sign Up to like & getrecommendations! Published in 2021 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2021.04.010
Abstract: (R,S)-ketamine causes rapid-acting and sustained antidepressant effects in treatment-resistant patients with depression although the precise molecular mechanisms underlying its antidepressant action remain unclear. We recently reported that transforming growth factor (TGF)-β1 might contribute to the… read more here.
Keywords: trkb signaling; rapid acting; like effects; intranasal administration ... See more keywords
Cognitive effects of rapid-acting treatments for resistant depression: Just adverse, or contributing to clinical efficacy?
Sign Up to like & getrecommendations! Published in 2021 at "Journal of psychiatric research"
DOI: 10.1016/j.jpsychires.2021.06.026
Abstract: Major Depressive Disorder is a major public health problem and has a high rate of treatment resistance. Fear conditioning has been proposed as a potential mechanism sustaining negative affect in mood disorders. With the aim… read more here.
Keywords: rapid acting; efficacy; cognitive effects; treatments resistant ... See more keywords
A wake-up call: Sleep physiology and related translational discrepancies in studies of rapid-acting antidepressants
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DOI: 10.1016/j.pneurobio.2021.102140
Abstract: Depression is frequently associated with sleep problems, and clinical improvement often coincides with the normalization of sleep architecture and realignment of circadian rhythm. The effectiveness of treatments targeting sleep in depressed patients, such as sleep… read more here.
Keywords: wake call; acting antidepressants; rapid acting; physiology ... See more keywords
Discovery of Rapid-Acting, Orally Available Antidepressants by Activating TrkB Signaling.
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DOI: 10.1021/acs.jmedchem.5c01750
Abstract: Major depressive disorder (MDD) remains a significant global health burden, and its current treatments are limited by the delayed onset of efficacy weeks after dosing. While esketamine and psychedelics were clinically successful as rapid-acting antidepressants… read more here.
Keywords: orally available; available antidepressants; discovery rapid; rapid acting ... See more keywords
Efficacy and safety of Tregopil, a novel, ultra-rapid acting oral prandial insulin analog, as part of a basal-bolus regimen in type 2 diabetes: a randomized, active-controlled phase 2/3 study
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Pharmacotherapy"
DOI: 10.1080/14656566.2022.2141569
Abstract: ABSTRACT Background Efficacy and safety of ultra-rapid acting oral prandial insulin Tregopil was compared with insulin aspart (IAsp) in patients with type 2 diabetes (T2D) on insulin glargine and metformin. Research design and methods In… read more here.
Keywords: rapid acting; safety; iasp; tregopil ... See more keywords
Rapid-acting antidepressant drugs modulate affective bias in rats
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DOI: 10.1126/scitranslmed.adi2403
Abstract: How rapid-acting antidepressants (RAADs), such as ketamine, induce immediate and sustained improvements in mood in patients with major depressive disorder (MDD) is poorly understood. A core feature of MDD is the prevalence of cognitive processing… read more here.
Keywords: rapid acting; acting antidepressant; bias; affective bias ... See more keywords
Regular human insulins versus rapid-acting insulin analogues in children and adolescents with type 1 diabetes: a protocol for a systematic review with meta-analysis and Trial Sequential Analysis
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DOI: 10.1186/s13643-024-02729-4
Abstract: Type 1 diabetes is a serious, chronic disorder with an increasing incidence among children and adolescents. Glycemic control in individuals with type 1 diabetes is better managed through a basal-bolus regimen with either regular human… read more here.
Keywords: regular human; rapid acting; insulin analogues; children adolescents ... See more keywords
Real-World Analysis of Rapid-Acting Insulin Analog Use and Its Blood Glucose Lowering Effect in Patients with Type 2 Diabetes Mellitus: Results from PASSION Disease Registry in Korea
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DOI: 10.2147/dmso.s334944
Abstract: Purpose Although rapid-acting insulins (RAIs) are used frequently in Korean clinical settings, evidence on their use is limited. This study explores the pattern and clinical effectiveness of the use of RAIs in Korean patients with… read more here.
Keywords: patients type; rapid acting; day; type diabetes ... See more keywords
Rapid-Acting Antidepressants.
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DOI: 10.2174/1381612824666180730104707
Abstract: BACKGROUND Conventional antidepressants are thought to produce their impact on clinical symptoms by increasing the central availability of biogenic amine neurotransmitters (the monoamine hypothesis of depression). These drugs continue to be the primary medicines used… read more here.
Keywords: acting antidepressants; rapid acting;