Rapid antidepressant‐like effect of Fructus Aurantii depends on cAMP‐response element binding protein/Brain‐derived neurotrophic facto by mediating synaptic transmission
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DOI: 10.1002/ptr.6812
Abstract: Several studies reported the relative antidepressant effects of Fructus Aurantii (FRA) with repeated treatment, the rapid antidepressant effects of FRA and the underlying mechanisms remained unclear. We, therefore, examined the rapid antidepressant actions of FRA… read more here.
Keywords: camp response; fructus aurantii; element binding; rapid antidepressant ... See more keywords
New Insight Into the Mechanisms of Fast-Acting Antidepressants: What We Learn From Scopolamine
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DOI: 10.1016/j.biopsych.2017.11.001
Abstract: For a depressed patient, a single day without symptom improvement means yet another day of suffering. The currently available antidepressants require weeks or months to achieve appreciable symptom remission and remain ineffective in a large… read more here.
Keywords: acting antidepressants; new insight; fast acting; rapid antidepressant ... See more keywords
Signaling pathways responsible for the rapid antidepressant-like effects of a GluN2A-preferring NMDA receptor antagonist
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DOI: 10.1038/s41398-018-0131-9
Abstract: In a previous study we found that the preferring GluN2A receptor antagonist, NVP-AAM077, elicited rapid antidepressant-like effects in the forced swim test that was related to the release of glutamate and serotonin in the medial… read more here.
Keywords: receptor antagonist; rapid antidepressant; like effects; antidepressant like ... See more keywords
Synergistic effects of two naturally occurring iridoids in eliciting a rapid antidepressant action by up‐regulating hippocampal PACAP signalling
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DOI: 10.1111/bph.15847
Abstract: Current mainstream antidepressants have limited efficacy with a delayed onset of action. Yueju, a herbal medicine, has a rapid antidepressant action. Identification of the active ingredients in Yueju and the mechanism/s involved was carried out. read more here.
Keywords: effects two; antidepressant action; synergistic effects; action ... See more keywords
Involvement of NMDA-AKT-mTOR Signaling in Rapid Antidepressant-Like Activity of Chaihu-jia-Longgu-Muli-tang on Olfactory Bulbectomized Mice
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DOI: 10.3389/fphar.2018.01537
Abstract: Background: Fast-onset antidepressants are urgently needed. Chaihu-jia-Longgu-Muli-tang (CLM), a classic Chinese herbal medicine, has been used for antidepressant treatment with long history. Olfactory bulbectomization (OB) model is validated for identification of rapid antidepressant efficacy. Here… read more here.
Keywords: clm; mice; rapid antidepressant; akt mtor ... See more keywords
Screening for Neuroprotective and Rapid Antidepressant-like Effects of 20 Essential Oils
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DOI: 10.3390/biomedicines11051248
Abstract: Depression is a serious psychiatric disorder with high prevalence, and the delayed onset of antidepressant effects remains a limitation in the treatment of depression. This study aimed to screen essential oils that have the potential… read more here.
Keywords: neuroprotective rapid; antidepressant like; essential oils; antidepressant ... See more keywords