Intracellular NO-Generator Based on Enzyme Trigger for Localized Tumor-Cytoplasm Rapid Drug Release and Synergetic Cancer Therapy.
Sign Up to like & getrecommendations! Published in 2019 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.8b17750
Abstract: Nitric oxide (NO) is an important biological messenger implicated in tumor therapy. However, current NO release systems suffer from some disadvantages, such as hydrolysis during blood circulation, poor specificity, and robust irradiation for stimuli. Accordingly,… read more here.
Keywords: tumor; rapid drug; generator; tumor cytoplasm ... See more keywords
Targeting the Oncogene KRAS Mutant Pancreatic Cancer by Synergistic Blocking of Lysosomal Acidification and Rapid Drug Release.
Sign Up to like & getrecommendations! Published in 2019 at "ACS nano"
DOI: 10.1021/acsnano.8b08246
Abstract: Survival of KRAS mutant pancreatic cancer is critically dependent on reprogrammed metabolism including elevated macropinocytosis, autophagy, and lysosomal degradation of proteins. Lysosomal acidification is indispensable to protein catabolism, which makes it an exploitable metabolic target… read more here.
Keywords: mutant pancreatic; rapid drug; pancreatic cancer; drug release ... See more keywords
Rapid drug screen using 3D tumor organoids
Sign Up to like & getrecommendations! Published in 2018 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aar7507
Abstract: Breast cancer organoids enable high-throughput functional drug screens to potentially guide individualized therapy. Breast cancer organoids enable high-throughput functional drug screens to potentially guide individualized therapy. read more here.
Keywords: screen using; rapid drug; tumor organoids; drug ... See more keywords