A theory of rapid evolutionary change explaining the de novo appearance of megakaryocytes and platelets in mammals.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cell science"
DOI: 10.1242/jcs.260286
Abstract: Platelets are found only in mammals. Uniquely, they have a log Gaussian volume distribution and are produced from megakaryocytes, large cells that have polyploid nuclei. In this Hypothesis, we propose that a possible explanation for… read more here.
Keywords: cell; change; evolutionary change; megakaryocytes platelets ... See more keywords
Rapid evolutionary repair by secondary perturbation of a primary disrupted transcriptional network.
Sign Up to like & getrecommendations! Published in 2023 at "EMBO reports"
DOI: 10.15252/embr.202256019
Abstract: The discrete steps of transcriptional rewiring have been proposed to occur neutrally to ensure steady gene expression under stabilizing selection. A conflictâfree switch of a regulon between regulators may require an immediate compensatory evolution to… read more here.
Keywords: secondary perturbation; rapid evolutionary; evolutionary repair; repair secondary ... See more keywords